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Bloodstream infections are a significant cause of mortality and morbidity in premature and low-birth-weight infants; due to non-specific manifestations, ‘rule out sepsis’ evaluations are commonly performed in the age group. After evaluation, broad spectrum antibiotics are administered while awaiting the results of bacterial cultures that have a yield of not more than 25%–27%.1 ,2
Viral causes of sepsis-like syndromes in the neonatal intensive care unit (NICU) have been underexplored, especially in the PCR era. Because a large majority of putatively septic episodes fail to yield a bacterial pathogen, we hypothesised that culture-negative septic episodes in very low-birth-weight NICU patients might have a viral origin.
The objective of the study was to identify non-respiratory viral causes of sepsis-like illness.
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