Online First

May 16, 2022

May 12, 2022

May 11, 2022

  • Original research
    Effects of the SARS-CoV-2 pandemic on perinatal activity in Yorkshire and the Humber region during 2020: an interrupted time series analysis
    Andrei Scott Morgan, Charlotte Bradford, Hilary Farrow, Elizabeth S Draper, Cath Harrison

    This interrupted time series analyses identified decreased rates of antenatal transfers for threatened extreme preterm delivery decreased rates of admission to neonatal intensive care for babies born extremely preterm and increased stillbirth rates during the 2020 SARS-CoV-2 pandemic in the Yorkshire and Humber region.

  • Original research
    Vestibular and balance dysfunction in children with congenital CMV: a systematic review
    Annalie Shears, Georgina Yan, Harriet Mortimer, Elizabeth Cross, Shari Sapuan, Seilesh Kadambari, Suzanne Luck, Paul T Heath, Simone Walter, Katy J Fidler

    This systematic literature review found congenital infection with cytomegalovirus (cCMV) to be associated with vestibular dysfunction in both symptomatic and asymptomatic children, with and without hearing loss. This highlights the importance of audiovestibular assessments when following-up children with cCMV.

May 09, 2022

May 03, 2022

May 02, 2022

  • Original research
    Single versus continuous sustained inflations during chest compressions and physiological-based cord clamping in asystolic lambs
    Georg M Schmölzer, Calum T Roberts, Douglas A Blank, Shiraz Badurdeen, Suzanne L Miller, Kelly J Crossley, Vanesa Stojanovska, Robert Galinsky, Martin Kluckow, Andrew W Gill, Stuart B Hooper, Graeme R Polglase

    In this study of resuscitation from asystole in newborn lambs there was no advantage to the use of continual sustained inflations as part of the cardiopulmonary resuscitation (CPR) strategy. Some haemodynamic measures were improved when CPR was provided with the umbilical cord intact in comparison with CPR after cord clamping.

  • Original research
    Social inequalities in access to care at birth and neonatal mortality: an observational study
    Morgane Michel, Corinne Alberti, Jean-Claude Carel, Karine Chevreul

    This manuscript examines all live births in France from 2012 - 2014 to assess the association between socioeconomic status and delivery of preterm infants in the appropriate level of maternity and neonatal care. The authors found such an association, as well as a higher risk of neonatal mortality.

April 27, 2022

April 20, 2022

  • Original research
    Comparison of neonatal morbidity and mortality between single-room and open-bay care: a retrospective cohort study
    Sophie Jansen, Romy J M Berkhout, Arjan B te Pas, Sylke J Steggerda, Linda S de Vries, Nicoline Schalij-Delfos, Alieke van der Hoeven, Enrico Lopriore, Vincent Bekker

    In this retrospective cohort study of the outcomes of infants born <32 week's gestation, moving from a traditional open bay neonatal unit to a new single-room unit was not associated with significant improvements in morbidity or mortality.

April 15, 2022

April 11, 2022

  • Original research
    Trends in the use of non-invasive respiratory support for term infants in tertiary neonatal units in Australia and New Zealand
    Brett J Manley, Adam G Buckmaster, Javeed Travadi, Louise S Owen, Calum T Roberts, Ian M R Wright, Peter G Davis, Gaston Arnolda and the Australian and New Zealand Neonatal network (ANZNN)

    This manuscript reports the use of non-invasive ventilation (NIV) in term infants in Australia from 2010 - 2018. The use of NIV increased on average 9% per year. There was an associated increase in the rate of pneumothorax and surfactant use over the same period.

April 08, 2022

  • Original research
    SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants
    Louise Makarious, Arthur Teng, Ju Lee Oei

    This meta-analyses of 4,238,685 children from high-income countries found that while prenatal exposure to any drugs of dependency increased SIDS risk this was greatest for infants prenatally exposed to opioids and methadone. Further research to examine associations in low- and middle-income countries is needed.

April 06, 2022

March 31, 2022

March 14, 2022

March 10, 2022

  • Original research
    Time to positivity of blood cultures in neonatal late-onset bacteraemia
    Sagori Mukhopadhyay, Sara M Briker, Dustin D Flannery, Miren B Dhudasia, Sarah A Coggins, Emily Woodford, Eileen M Walsh, Sherian Li, Karen M Puopolo, Michael W Kuzniewicz

    In a large retrospective cohort study, most blood cultures drawn after 72 hours for suspected bacteremia and not coagulase negative staphylococcus, were reported positive by 36 hours.

March 07, 2022

  • Original research
    Saliva cortisol diurnal variation and stress responses in term and preterm infants
    David Q Stoye, James P Boardman, Clive Osmond, Gemma Sullivan, Gillian Lamb, Gill S Black, Natalie Z M Homer, Nina Nelson, Elvar Theodorsson, Evalotte Mörelius, Rebecca M Reynolds

    Results from salivary cortisol concentrations of infants at 4 months of age suggests that extremely preterm birth disrupts the normative development of the HPA axis in infancy, with patterns of cortisol secretion resembling those seen after childhood adversity.

March 02, 2022

  • Original research
    Two-year neurodevelopmental outcome in children born extremely preterm: the EPI-DAF study
    Pauline E van Beek, Monique Rijken, Lisa Broeders, Hendrik J ter Horst, Corine Koopman-Esseboom, Ellen de Kort, Céleste Laarman, Susanne M Mulder-de Tollenaer, Katerina Steiner, Renate MC Swarte, Elke van Westering-Kroon, S Guid Oei, Aleid G Leemhuis, Peter Andriessen on behalf of the EPI-DAF study group

    In a Dutch national cohort of infants born 24+0 to 26+6/7 weeks gestation born after changes to guidelines supporting active treatment at 24+0 weeks, the majority did not have neurodevelopmental impairment at 2-year follow up as defined in this study.

March 01, 2022

February 28, 2022

February 25, 2022

  • Original research
    Predictors of anastomotic strictures following œsophageal atresia repair
    Madeleine Aumar, Rony Sfeir, Adeline Pierache, Dominique Turck, Frederic Gottrand on behalf of CRACMO

    Large study of all babies born with oesophageal atresia in France over an 8 year period with follow up to 1 year. Anastomotic stricture identified in 23% of cases with independent risk factors identified including one (delayed anastomosis) previously unreported.

February 21, 2022

February 16, 2022

February 09, 2022

  • Original research
    Preliminary study of automated oxygen titration at birth for preterm infants
    Sanoj KM Ali, Rohan V Jayakar, Andrew P Marshall, Timothy J Gale, Peter A Dargaville

    Before-after trial of using automated oxygen control in the delivery room, showing similar results as with manual control (70 vs. 60%) for %time in target, and significantly less time spent in potential hyperoxaemia.

February 08, 2022

  • Short report
    Haemodynamic changes with varying chest compression rates in asphyxiated piglets
    Marlies Bruckner, Mattias Neset, Megan O'Reilly, Tze-Fun Lee, Po-Yin Cheung, Georg M Schmölzer

    In this paper, the authors found that incremental increases in the rate of chest compressions up to 180/min improved cardiac output in asphyxiated piglets receiving cardiopulmonary resuscitation with sustained inflations.

January 31, 2022

  • Original research
    Lung volume distribution in preterm infants on non-invasive high-frequency ventilation
    Vincent D Gaertner, Andreas D Waldmann, Peter G Davis, Dirk Bassler, Laila Springer, Jessica Thomson, David Gerald Tingay, Christoph Martin Rüegger

    Randomized crossover trial comparing electrical impedance tomography (EIT) data between nHFOV with nCPAP, showing increased and more homogenous lung aeration with nHFOV compared to nCPAP

January 28, 2022

January 25, 2022

January 21, 2022

January 20, 2022

December 24, 2021

  • Review
    Neonatal and fetal therapy of congenital diaphragmatic hernia-related pulmonary hypertension
    Felix R De Bie, Catherine M Avitabile, Luc Joyeux, Holly L Hedrick, Francesca M Russo, David Basurto, Jan Deprest, Natalie E Rintoul

    This review looks at the current clinically available neonatal and fetal therapies targeting congenital diaphragmatic hernia and the associated pulmonary hypertension, and considers the most promising experimental treatments and future research.

December 23, 2021

December 20, 2021

December 16, 2021

  • Original research
    Outcome of non-cooled asphyxiated infants with under-recognised or delayed-onset encephalopathy
    Corline E J Parmentier, Sylke J Steggerda, Lauren C Weeke, Monique Rijken, Linda S De Vries, Floris Groenendaal

    In a retrospective cohort study, all infants with perinatal asphyxia and early seizure onset who did not receive therapeutic hypothermia had MRI abnormalities and half died or had poor neurodevelopmental outcome.

December 15, 2021

December 03, 2021

December 02, 2021

  • Original research
    Effect of prophylactic dextrose gel on the neonatal gut microbiome
    Sophie L St Clair, Jane E Harding, Justin M O’Sullivan, Gregory D Gamble, Jane M Alsweiler, Tommi Vatanen for the hPOD Study Group

    This observational study nested in an RCT of oral dextrose gel vs placebo to prevent hypoglycaemia in term infants, explores whether dextrose gel has an impact on the neonatal gut microbiome.

November 29, 2021