Online First

January 25, 2022

January 21, 2022

January 20, 2022

December 24, 2021

  • Review
    Neonatal and fetal therapy of congenital diaphragmatic hernia-related pulmonary hypertension
    Felix R De Bie, Catherine M Avitabile, Luc Joyeux, Holly L Hedrick, Francesca M Russo, David Basurto, Jan Deprest, Natalie E Rintoul

    This review looks at the current clinically available neonatal and fetal therapies targeting congenital diaphragmatic hernia and the associated pulmonary hypertension, and considers the most promising experimental treatments and future research.

December 23, 2021

December 20, 2021

December 16, 2021

December 15, 2021

December 03, 2021

December 02, 2021

  • Original research
    Effect of prophylactic dextrose gel on the neonatal gut microbiome
    Sophie L St Clair, Jane E Harding, Justin M O’Sullivan, Gregory D Gamble, Jane M Alsweiler, Tommi Vatanen for the hPOD Study Group

    This observational study nested in an RCT of oral dextrose gel vs placebo to prevent hypoglycaemia in term infants, explores whether dextrose gel has an impact on the neonatal gut microbiome.

November 29, 2021

November 25, 2021

November 24, 2021

  • Original research
    Randomised crossover trial comparing algorithms and averaging times for automatic oxygen control in preterm infants
    Christoph E Schwarz, Karen B Kreutzer, Lukas Langanky, Nicole S Wolf, Wolfgang Braun, Marc Paul O'Sullivan, Christian F Poets, Axel R Franz

    In this randomised crossover study in 24 oxygen dependent preterm infants on non-invasive respiratory support, modifications to an established automated oxygen controller did not improve time in intended SpO₂ range. There was no difference in performance whether the oximeter SpO₂ averaging time was set to 2 seconds or 8 seconds.

November 23, 2021

  • Original research
    Parental perspective on important health outcomes of extremely preterm infants
    Magdalena Jaworski, Annie Janvier, Claude Julie Bourque, Thuy-An Mai-Vo, Rebecca Pearce, Anne R Synnes, Thuy Mai Luu

    Parents of extremely preterm born children undergoing follow up rated their children's health as 9/10. Parental priorities for health improvement were related to behaviour, emotional health and language communication, respiratory health and feeding/growth issues.

November 22, 2021

November 18, 2021

November 17, 2021

  • Original research
    Impact of maternal obesity on neonatal heart rate and cardiac size
    Alan M Groves, Anthony N Price, Tamarind Russell-Webster, Simone Jhaveri, Yang Yang, Ellie E Battersby, Shiffa Shahid, Matais Costa Vieira, Emer Hughes, Faith Miller, Annette L Briley, Claire Singh, Paul T Seed, Phillip J Chowienczyk, Kenan W D Stern, Jennifer Cohen, Dharmintra Pasupathy, A David Edwards, Lucilla Poston, Paul D Taylor

    This manuscript examines the impact of preconception maternal obesity on measures of cardiac size and function assessed by MRI. The authors compared ECG findings and cardiac MRI findings in infants delivered to normal BMI and obese women. They found a higher resting heart rate and lower LV end diastolic volume and stroke volumes in infants who were born to obese women. They speculate that these findings may be related to increased CV risk in offspring of obese mothers.

November 15, 2021

  • Original research
    Five-minute Apgar score and outcomes in neonates of 24–28 weeks’ gestation
    Prakesh S Shah, Mikael Norman, Franca Rusconi, Satoshi Kusuda, Brian Reichman, Malcolm Battin, Dirk Bassler, Neena Modi, Stellan Hakansson, Jie Yang, Shoo K Lee, Kjell Helenius, Maximo Vento, Liisa Lehtonen, Mark Adams, Tetsuya Isayama, Kei Lui, Luigi Gagliardi on behalf of International Network for Evaluating Outcomes of Neonates (iNeo) Investigators

    In a large multicenter retrospective study of extremely preterm infants, increasing 5-minute Apgar scores were associated with decreasing mortality but low scores did not predict severe neurologic injury in survivors.

November 09, 2021

  • Original research
    Dual-site blood culture yield and time to positivity in neonatal late-onset sepsis
    Sarah A Coggins, Mary Catherine Harris, Lakshmi Srinivasan

    Observational, single-centre study questioning the need to obtain both, peripheral and catheter-based, blood cultures in infants with suspected sepsis - the answer is yes, we need both if we do not want to miss a positive result in a significant proportion of infants.

November 01, 2021

October 25, 2021

October 22, 2021

October 19, 2021

October 16, 2021

October 07, 2021

  • Original research
    Neonatal-onset mitochondrial disease: clinical features, molecular diagnosis and prognosis
    Tomohiro Ebihara, Taro Nagatomo, Yohei Sugiyama, Tomoko Tsuruoka, Yoshiteru Osone, Masaru Shimura, Makiko Tajika, Tetsuro Matsuhashi, Keiko Ichimoto, Ayako Matsunaga, Nana Akiyama, Minako Ogawa-Tominaga, Yukiko Yatsuka, Kazuhiro R Nitta, Yoshihito Kishita, Takuya Fushimi, Atsuko Imai-Okazaki, Akira Ohtake, Yasushi Okazaki, Kei Murayama

    The authors analyzed neonatal-onset mitochondrial disease in Japan via a retrospective observational study to clarify its clinical features, molecular diagnosis, and prognosis. The heterogeneous aetiology if the group is outlined.

  • Letter
    Outcomes of establishing a neonatal peripheral vascular access team
    Matheus van Rens, Kevin Hugill, Mohammed Abdul Khader Gaffari, Airene V Francia, Thiruveni Ramkumar, Krisha L P Garcia, Fredericus H J van Loon

October 04, 2021

September 29, 2021

  • Original research
    Comparison of intraosseous and intravenous epinephrine administration during resuscitation of asphyxiated newborn lambs
    Calum T Roberts, Sarah Klink, Georg M Schmölzer, Douglas A Blank, Shiraz Badurdeen, Kelly J Crossley, Karyn Rodgers, Valerie Zahra, Alison Moxham, Charles Christoph Roehr, Martin Kluckow, Andrew William Gill, Stuart B Hooper, Graeme R Polglase

    When intravenous access is not easily attainable, recommendations are to use intra-osseus as an alternative route for adrenaline administration in neonatal resuscitation. In an non-randomized trial in a lamb model, these two delivery routes were equivalent in terms of success in resuscitation and serum adrenaline levels.

  • Original research
    Antenatal corticosteroids and neurodevelopmental outcomes in late preterm births
    Amir Aviram, Kellie Murphy, Sarah McDonald, Elizabeth Asztalos, Arthur Zaltz, Donald Redelmeier, Baiju Shah, Jon Barrett, Nir Melamed

    In a large population-based dataset of live births at 34-36 weeks' gestation born 2006-2011, exposure to antenatal corticosteroids earlier in gestation may be associated with an increased risk for neurodevelopmental concerns and healthcare utilization at 5-9 years.

September 23, 2021

September 22, 2021

  • Original research
    Implementation of an adapted Sepsis Risk Calculator algorithm to reduce antibiotic usage in the management of early onset neonatal sepsis: a multicentre initiative in Wales, UK
    Nitin Goel, Stephanie Cannell, Gemma Davies, Murali Sridhar Natti, Vickness Kirupaalar, Artur Abelian, Shakir Saeed, Rhian Smith, Ravi Manikonda, Prem Kumar Pitchaikani, Dawn Davies, Rachel May Morris, Lynsey Edwards, Roopashree Govindaraju, Kate Creese, Jane Jones, Jalil Choudhary, Sarah Rowley, Chidambaram Sethuraman, Helen Muxworthy, Felicity Curtis, Patricia Donnelly, Manohar Joishy, Ian Barnard, Celyn Kenny, Rajarshi Pal, Karen Jones, Sujoy Banerjee

    Antibiotic use in the newborn may have long lasting impact. Neonatal sepsis is relatively rare but one which causes concern, investigation and treatment. This paper describes the implementation of an sepsis risk calculator to reduce antibiotic use in a safe and sustainable way.