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January 30, 2023
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December 30, 2022
December 26, 2022
December 23, 2022
December 20, 2022
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December 09, 2022
December 07, 2022
December 01, 2022
November 24, 2022
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November 18, 2022
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November 15, 2022
November 09, 2022
- Original researchImmunoreactive trypsinogen in healthy newborns and infants with cystic fibrosis
Newborn screening programmes for cystic fibrosis (CF) are based on levels of immuno-reactive trypsinogen (IRT). This study highlights the importance of gestational age and day of sampling in interpreting these results and emphasises the importance of a second IRT for inconclusive diagnoses.
November 07, 2022
- Original researchNasal high-flow therapy to Optimise Stability during Intubation: the NOSI pilot trial
Pilot study investigating the feasibility of blinding the use of high-flow nasal cannula oxygen during neonatal intubation and showing no effect on the proportion of time spent in hypoxemia.
November 03, 2022
October 28, 2022
October 21, 2022
- Original researchChange in neurodevelopmental outcomes for extremely premature infants over time: a systematic review and meta-analysis
In a systematic review and meta-analysis, there was no significant change in neurodevelopmental impairment rates reported between 1990 and 2020 when comparing same-center cohorts. This finding points to need for family-focused and brain health interventions to improve outcomes.
October 19, 2022
- Original researchDo newborn infants exhale through the CPAP system? Secondary analysis of a randomised cross-over trial
In this study, investigators demonstrate for the first time that newborns receiving low levels of CPAP pressure are able to exhale through the CPAP circuit.
- Original researchViews of parents, adults born preterm and professionals on linkage of real-world data of preterm babies
In a mixed methods approach involving focus groups, interviews, and a national survey, this study found that parents, adults born preterm, and professionals are supportive of routine linkage of health and education data for research focused on improving outcomes.
- Original researchPredicting the likelihood of lower respiratory tract Ureaplasma infection in preterms
Predictive models to determine the likelihood of lower respiratory tract Ureaplasma infection were developed based on perinatal clinical information available.These models may be useful in the design of clinical trials of therapeutic interventions to prevent Ureaplasma-mediated BPD.
October 17, 2022
- Original researchExposure to umbilical cord management approaches and death or neurodevelopmental impairment at 22–26 months’ corrected age after extremely preterm birth
This retrospective study followed 1900 infants born < 27 weeks’ gestation to two years’ corrected age. Infants undergoing delayed cord clamping had lower rates of death or severe neurodevelopmental impairment. The effect was not mediated by severe intraventicular haemorrhage.
October 12, 2022
- Original researchDiaphragm electrical activity during weaning of nasal high-flow therapy in preterm infants
Investigators in this manuscript examined electrical activity of the diaphragm (Edi) in 40 preterm infants during pre-specified weaning of high flow nasal cannula. Edi significantly increased only after the final wean from 2L/min of flow, suggesting increased work of breathing.
October 07, 2022
- ReviewDiversity and trends of human milk banking: a scoping review from 1946 to 2021
This scoping review describes the published information on banked donor human milk and highlights areas for future research and increased access.
September 29, 2022
September 27, 2022
- Original researchManagement of pneumothorax in neonatal retrieval: a retrospective cohort study
In a small retrospective cohort study of infants with pneumothorax, incidence of deterioration and need for an intercostal catheter was low during transport without an intercostal catheter.
September 26, 2022
September 14, 2022
- Original researchUse of ventilation/perfusion mismatch to guide individualised CPAP level selection in preterm infants: a feasibility trial
Study showing that by determining the extent of V’/Q’ mismatch during CPAP treatment non-invasively, an ideal individual CPAP level can be determined, which in their sample was at 7 (5-8) cm H2O.
September 06, 2022
- Original researchSociodemographic risk factors, parental stress and social support in the neonatal intensive care unit
This research emphasises the importance of the role of social support in modifying the effects of parent experiences of stress in the NICU at the time of discharge. The study shows that socio-demographic risk factors may not infer stress or risk in the anticipated direction: here, higher education and socio-economic status were associated with greater parental stress. Additionally, lower socioeconomic status, though associated with decreased social support, did not infer greater stress.
September 05, 2022
- Original researchLaryngeal mask airway versus face mask ventilation or intubation for neonatal resuscitation in low-and-middle-income countries: a systematic review and meta-analysis
Systematic review of studies comparing laryngeal mask airway (FMA) with face mask for respiratory stabilisation immediately after birth showing that failure rates with LMA are much lower than with face masks (RR: 0.24).
August 29, 2022
- Original researchLung volume changes during apnoeas in preterm infants
Well-done study comparing end-expiratory lung volumes during apneas using EIT during nasal support via nCPAP vs. nHFOV in 30 infants. They found that lung volume decreased less during apnea while on nHFOV than during CPAP, and SpO2 was more stable.
- Original researchCaffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial
In late preterms (132 infants, 34-36 weeks), a randomized controlled trial (placebo, versus different caffeine citrate doses), caffeine reduces intermittent hypoxia events at 2 weeks of age, with 20 mg.kg-1.day-1 being the most effective dose.
August 25, 2022
- Original researchGrowth trajectory during the first 1000 days and later overweight in very preterm infants
Former very preterm born children that are overweight, underweight or normal at 5 or 15 years already had significant different BMI Z-scores by 2 years of age. Change in length Z-score during NICU stay might have a protective effect against later overweight or obesity.