Online First

August 04, 2021

August 03, 2021

  • Original research
    Monitoring of carbon dioxide in ventilated neonates: a prospective observational study
    Tobias Werther, Lukas Aichhorn, Sina Stellberg, Francesco Stefano Cardona, Katrin Klebermass-Schrehof, Angelika Berger, Georg M Schmölzer, Michael Wagner

    This study comparing the precision and accuracy of end-tidal and transcutaneous pCO2 with arterial measurements found that end-tidal CO2, measured through a double-lumen ET tube in ventilated neonates, was superior to tcpCO2.

August 02, 2021

July 30, 2021

July 29, 2021

July 28, 2021

  • Original research
    Temporal trends in respiratory care and bronchopulmonary dysplasia in very preterm infants over a 10-year period in Spain
    Alejandro Avila-Alvarez, Carlos Zozaya, Sonia Pértega-Diaz, Manuel Sanchez-Luna, Martin Iriondo-Sanz, Maria Dolores Elorza, Fermín García-Muñoz Rodrigo Spanish Neonatal Network SEN1500

    National survey of changes in respiratory outcomes of VLBW infants over 2 periods, showing that outcome did not improve despite an increase in the use of non-invasive ventilation.

  • Original research
    Oesophageal atresia: sonographic signs may prenatally predict surgical complexity
    Tal Weissbach, Anya Kushnir, Ella Haber Kaptsenel, Leah Leibovitch, Ron Bilik, Daniel Shinhar, Gideon Karplus, Reuven Achiron, Zvi Kivilevitch, Eran Barzilay, Shali Mazaki Tovi, Boaz Weisz, Eran Kassif

    This manuscript characterizes prenatal ultrasound findings of babies with esophageal atresia with the presence or absence of a distal fistula. The authors found several ultrasound parameters were correlated with more complex repair and absence of a distal fistula

  • Original research
    Direct swallowing training and oral sensorimotor stimulation in preterm infants: a randomised controlled trial
    Ju Sun Heo, Ee-Kyung Kim, Sae Yun Kim, In Gyu Song, Young Mi Yoon, Hannah Cho, Eun Sun Lee, Seung Han Shin, Byung-Mo Oh, Hyung-Ik Shin, Han-Suk Kim

    This single centre, masked RCT enrolling 186 infants <32 weeks gestation found that direct swallowing training combined with oral sensorimotor stimulation significantly shortened the time to independent oral feeding compared with no intervention.

July 19, 2021

July 14, 2021

July 13, 2021

  • Original research
    Growth in extremely preterm children born in England in 1995 and 2006: the EPICure studies
    Yanyan Ni, Rebecca Lancaster, Emmi Suonpera, Marialivia Bernardi, Amanda Fahy, Jennifer Larsen, Jayne Trickett, John R Hurst, Dieter Wolke, Samantha Johnson, Neil Marlow

    This paper describes the growth to age 11 of a sample of the EPICure 2 2006 preterm birth cohort, compared to healthy same age controls and to the 1995 EPICure cohort. Since 1995, childhood growth in weight, height and BMI have improved for births <26 weeks of gestation, but there was no improvement in head growth.

  • Original research
    Titres and neutralising capacity of SARS-CoV-2-specific antibodies in human milk: a systematic review
    Jia Ming Low, Yue Wey Low, Youjia Zhong, Cheuk Yiu Charlotte Lee, Ming Chan, Nicholas Beng Hui Ng, Zubair Amin, Yvonne Peng Mei Ng

    Systematic review on the titers and neutralising capacity of SARS-CoV-2-specific antibodies in human milk demonstrates that these antibodies can neutralise the virus in vitro. Furthermore, high pressure, but not Holder pasteurisation deactivates the specific IgAs.

  • Short report
    Discriminating necrotising enterocolitis and focal intestinal perforation
    Janet Berrington, Nicholas D Embleton
  • Original research
    Characteristics of neonatal herpes simplex virus infections in Germany: results of a 2-year prospective nationwide surveillance study
    André Kidszun, Anna Bruns, Daniel Schreiner, Susanne Tippmann, Julia Winter, Roman M Pokora, Michael S Urschitz, Eva Mildenberger

    This two-year prospective nationwide surveillance study of neonatal HSV infections finds few cases in Germany. Most children had few symptoms and good outcomes, but five infants had significant sequelae. Orofacial HSV infection was present in one or more family members for 20/23 babies where data was available, but it is not clear if this was the mode of transmission.

July 07, 2021

June 29, 2021

June 28, 2021

  • Original research
    Life-threatening bronchopulmonary dysplasia: a British Paediatric Surveillance Unit Study
    Rebecca Naples, Sridhar Ramaiah, Judith Rankin, Janet Berrington, Sundeep Harigopal

    The authors describe a prospective cohort of 153 babies with "life threatening BPD" defined as requiring positive pressure at 38 weeks corrected gestational age. Data were collected from the British Paediatric Surveillance Unit from June 2017 to July 2018. Findings include a high likelihood of serious morbidity and mortality, and large practice variation in therapies.

June 25, 2021

June 23, 2021

  • Original research
    Extubation generates lung volume inhomogeneity in preterm infants
    Risha Bhatia, Hazel R Carlisle, Ruth K Armstrong, C Omar Farouk Kamlin, Peter G Davis, David G Tingay

    Observational study using Electrical Impedance Tomography to confirm that lung volume is lost during transition from IPPV to CPAP.

  • Original research
    Parent-reported health status of preterm survivors in a Canadian cohort
    Satvinder Ghotra, David Feeny, Ronald Barr, Junmin Yang, Saroj Saigal, Michael Vincer, Jehier Afifi, Prakeshkumar S Shah, Shoo K Lee, Anne R Synnes Canadian Neonatal Follow-Up Network Investigators

    Among infants <29 weeks' gestation in the Canadian Neonatal Follow Up Network with parent-reported health status impact at 36 months, most reported none or mild concerns, and only ~ 1 in 4 reported moderate or severe concerns. Concerns were associated with a range of factors.

June 18, 2021

June 15, 2021

June 10, 2021

June 09, 2021

  • Original research
    Effect of breathing on venous return during delayed cord clamping: an observational study
    Emma Brouwer, Ronny Knol, Annie Kroushev, Thomas Van Den Akker, Stuart B Hooper, Arno A Roest, Arjan B te Pas

    Real-time echocardiographic monitoring of blood flow in the ductus venosus and hepatic vein was undertaken during perinatal transition with intact umbilical cord of term born infants. Antegrade flow increased during inspiration, preferentially directing blood flow from the ductus venosus into the right atrium.

  • Original research
    Aqueous chlorhexidine 1% versus 2% for neonatal skin antisepsis: a randomised non-inferiority trial
    Akash Sharma, Srikant Kulkarni, Anu Thukral, M Jeeva Sankar, Ramesh Agarwal, A K Deorari, Sarita Mohapatra, Thirumurthy Velpandian, Minu Bajpai

    This controlled trial tested different strengths of aqueous chlorhexidine for neonatal skin antisepsis prior to intravenous cannulation in a neonatal intensive care unit in India, finding that 1% chlorhexidine was effective, but not clearly equivalent to 2% which pending further research remains the recommended concentration for this purpose.

June 03, 2021

May 27, 2021

May 26, 2021

May 21, 2021

  • Original research
    Neuronal exosome proteins: novel biomarkers for predicting neonatal response to therapeutic hypothermia
    Beth Pineles, Arunmani Mani, Livia Sura, Candace Rossignol, Mehmet Albayram, Michael David Weiss, Laura Goetzl

    In an observational cohort study, exosome based central nervous system biomarkers from peripheral blood in newborns less than 12 hours old undergoing hypothermia for hypoxic-ischemic encephalopathy differentiated those with favorable and unfavorable MRI injury scores at 5-7 days.

May 20, 2021

May 14, 2021

  • Original research
    Early lung ultrasound affords little to the prediction of bronchopulmonary dysplasia
    Patricia Lee Woods, Benjamin Stoecklin, Amanda Woods, Andrew William Gill

    These investigators report a prospective analysis of preterm babies < 28 weeks gestation in whom lung ultrasounds were performed on a scheduled basis. They found that u/s was predictive in univariate analysis of the development of BPD, but added little to the predictive value when gestational age was included in the model.

  • Original research
    Neonatal arterial stroke location is associated with outcome at 2 years: a voxel-based lesion-symptom mapping study
    Christian Núñez, Christian Stephan-Otto, Gemma Arca, Thais Agut, Juan Arnaez, Malaika Cordeiro, Isabel Benavente-Fernández, Nuria Boronat, Simón Pedro Lubián-López, Eva Valverde, Montesclaros Hortigüela, Alfredo García-Alix

    In a prospective observational multicenter study of neonatal stroke, lesion location identified by MRI is associated with language, motor, and cognitive outcomes at two years of age.

  • Short report
    Nasal expression of SARS-CoV-2 entry receptors in newborns
    Santtu Heinonen, Otto Helve, Sture Andersson, Cecilia Janér, Liina Süvari, Anu Kaskinen

    Low nasal expression of SARS-CoV-2 entry receptors in newborns in both preterm and term cases may contribute to the low attack rates and mild disease in newborns.

May 10, 2021