Online First

September 29, 2022

September 27, 2022

  • Original research
    Management of pneumothorax in neonatal retrieval: a retrospective cohort study
    Ikhwan Halibullah, Fiona Hammond, Kate Hodgson, Natalie Duffy, Michael Stewart, Arun Sett

    In a small retrospective cohort study of infants with pneumothorax, incidence of deterioration and need for an intercostal catheter was low during transport without an intercostal catheter.

September 26, 2022

September 14, 2022

September 06, 2022

  • Original research
    Sociodemographic risk factors, parental stress and social support in the neonatal intensive care unit
    Tamiko Younge, Marni Jacobs, Lisa Tuchman, Randi Streisand, Lamia Soghier, Karen Fratantoni

    This research emphasises the importance of the role of social support in modifying the effects of parent experiences of stress in the NICU at the time of discharge. The study shows that socio-demographic risk factors may not infer stress or risk in the anticipated direction: here, higher education and socio-economic status were associated with greater parental stress. Additionally, lower socioeconomic status, though associated with decreased social support, did not infer greater stress.

September 05, 2022

August 29, 2022

  • Original research
    Lung volume changes during apnoeas in preterm infants
    Vincent D Gaertner, Andreas D Waldmann, Peter G Davis, Dirk Bassler, Laila Springer, David Gerald Tingay, Christoph Martin Rüegger

    Well-done study comparing end-expiratory lung volumes during apneas using EIT during nasal support via nCPAP vs. nHFOV in 30 infants. They found that lung volume decreased less during apnea while on nHFOV than during CPAP, and SpO2 was more stable.

  • Original research
    Caffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial
    Elizabeth Anne Oliphant, Christopher JD McKinlay, David McNamara, Alana Cavadino, Jane M Alsweiler

    In late preterms (132 infants, 34-36 weeks), a randomized controlled trial (placebo, versus different caffeine citrate doses), caffeine reduces intermittent hypoxia events at 2 weeks of age, with 20 being the most effective dose.

August 25, 2022

  • Original research
    Growth trajectory during the first 1000 days and later overweight in very preterm infants
    Laure Simon, Alice Hadchouel, Catherine Arnaud, Anne Frondas-Chauty, Stéphane Marret, Cyril Flamant, Dominique Darmaun, Christophe Delacourt, Laetitia Marchand-Martin, Pierre Yves Ancel, Jean-Christophe Roze

    Former very preterm born children that are overweight, underweight or normal at 5 or 15 years already had significant different BMI Z-scores by 2 years of age. Change in length Z-score during NICU stay might have a protective effect against later overweight or obesity.

  • Original research
    Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study
    Carlos Zozaya, Niloofar Ganji, Bo Li, Maarten Janssen Lok, Carol Lee, Yuhki Koike, Estelle Gauda, Martin Offringa, Simon Eaton, Prakeshkumar S Shah, Agostino Pierro

    In a small phase 1 pilot study in preterm infants with suspected or confirmed necrotizing enterocolitis, cycles of remote ischemic conditioning with short duration of limb ischemia using a sphygmomanometer followed by reperfusion and rest was feasible and safe.

August 23, 2022

  • Original research
    Bronchopulmonary dysplasia and neurobehavioural outcomes at birth and 2 years in infants born before 30 weeks
    Monika Martin, Lynne Smith, Julie A Hofheimer, Elisabeth C McGowan, T Michael O'Shea, Steve Pastyrnak, Brian Scott Carter, Jennifer Helderman, Jennifer Check, Charles Neal, Mary B Roberts, Lynne M Dansereau, Sheri A Della Grotta, Barry M Lester

    In a prospective, multicenter study of infants < 30 weeks GA, BPD severity was associated with neurobehavioral outcomes at the time of hospital discharge as measured by NNNS, and with 2 year outcomes.

  • Original research
    Automatic oxygen control for reducing extremes of oxygen saturation: a randomised controlled trial
    Vrinda Nair, Prakash Kannan Loganathan, Mithilesh Kumar Lal, Helen Pringleton, Thomas Edward Bachman, Malcolm Brodlie, Paul Dixon

    In this randomised controlled trial that included 44 infants, servo controlled adjustment of FiO2 improved oxygen targeting over the duration of ventilation and nasal CPAP treatment.

August 11, 2022

August 08, 2022

August 05, 2022

July 28, 2022

  • Original research
    Early-onset neonatal sepsis in the Paris area: a population-based surveillance study from 2019 to 2021
    Paola Sikias, Valérie Biran, Laurence Foix-L'Hélias, Céline Plainvert, Pascal Boileau, Stéphane Bonacorsi the EOS study group

    This population surveillance study of infants ≥34 weeks' gestation reports the incidence of early-onset sepsis, causative organisms and antibiotic susceptibilities. Details of maternal Group B Streptococcus screening status and prophylactic treatment are provided.

July 18, 2022

July 14, 2022

July 05, 2022

July 04, 2022

June 30, 2022

June 24, 2022

  • Original research
    Lung ultrasound of the dependent lung detects real-time changes in lung volume in the preterm lamb
    Arun Sett, Kelly R Kenna, Rebecca J Sutton, Elizabeth J Perkins, Magdy Sourial, Jack D Chapman, Susan M Donath, Arun Sasi, Sheryle R Rogerson, Brett J Manley, Peter G Davis, Prue M Pereira-Fantini, David G Tingay

    In preterm newborn lambs, lung ultrasound of the dependent lung was able to detect large changes in total and regional lung volume in real-time and correctly identified opening and closing pressures but lacked the precision to detect small changes in lung volume.

June 22, 2022

June 21, 2022

  • Original research
    Online clinical tool to estimate risk of bronchopulmonary dysplasia in extremely preterm infants
    Rachel G Greenberg, Scott A McDonald, Matthew M Laughon, David Tanaka, Erik Jensen, Krisa Van Meurs, Eric Eichenwald, Jane E Brumbaugh, Andrea Duncan, Michele Walsh, Abhik Das, C Michael Cotten On behalf of Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

    This paper provides an update on the original NRN BPD risk estimator (2011) using data on >9000 very preterm infants born between 2011-2017. I think it ticks the boxes in terms of methodological validity, potential impact, interest and readability.

  • Images in neonatal medicine
    Eosinophilic pustular folliculitis of infancy
    Wu Guo, Ge Qian, Chang'e Zhang

June 15, 2022

  • Original research
    Acceleration during neonatal transport and its impact on mechanical ventilation
    Lajos Lantos, András Széll, David Chong, Zsolt Somogyvári, Gusztav Belteki

    This study addresses the impact of the neonatal transport environment on mechanical ventilation. The study provides some information on the forces neonates are exposed to during transport and the response of ventilation equipment to this.

  • Original research
    Early-onset sepsis in very preterm neonates in Australia and New Zealand, 2007–2018
    Husharn L Duggan, Sharon S W Chow, Nicola C Austin, Prakeshkumar S Shah, Kei Lui, Kenneth Tan on behalf of the Australian and New Zealand Neonatal Network

    In a retrospective study from the Australian New Zealand Neonatal Network database, incidence of early onset sepsis in infants less than 32 weeks gestation was stable over 12 years, and incidence of e.coli, the predominant organism, increased.

May 26, 2022

May 16, 2022

May 12, 2022

May 11, 2022

  • Original research
    Effects of the SARS-CoV-2 pandemic on perinatal activity in Yorkshire and the Humber region during 2020: an interrupted time series analysis
    Andrei Scott Morgan, Charlotte Bradford, Hilary Farrow, Elizabeth S Draper, Cath Harrison

    This interrupted time series analyses identified decreased rates of antenatal transfers for threatened extreme preterm delivery decreased rates of admission to neonatal intensive care for babies born extremely preterm and increased stillbirth rates during the 2020 SARS-CoV-2 pandemic in the Yorkshire and Humber region.

  • Original research
    Vestibular and balance dysfunction in children with congenital CMV: a systematic review
    Annalie Shears, Georgina Yan, Harriet Mortimer, Elizabeth Cross, Shari Sapuan, Seilesh Kadambari, Suzanne Luck, Paul T Heath, Simone Walter, Katy J Fidler

    This systematic literature review found congenital infection with cytomegalovirus (cCMV) to be associated with vestibular dysfunction in both symptomatic and asymptomatic children, with and without hearing loss. This highlights the importance of audiovestibular assessments when following-up children with cCMV.

May 09, 2022

April 20, 2022

  • Original research
    Comparison of neonatal morbidity and mortality between single-room and open-bay care: a retrospective cohort study
    Sophie Jansen, Romy J M Berkhout, Arjan B te Pas, Sylke J Steggerda, Linda S de Vries, Nicoline Schalij-Delfos, Alieke van der Hoeven, Enrico Lopriore, Vincent Bekker

    In this retrospective cohort study of the outcomes of infants born <32 week's gestation, moving from a traditional open bay neonatal unit to a new single-room unit was not associated with significant improvements in morbidity or mortality.

April 15, 2022

April 11, 2022

  • Original research
    Trends in the use of non-invasive respiratory support for term infants in tertiary neonatal units in Australia and New Zealand
    Brett J Manley, Adam G Buckmaster, Javeed Travadi, Louise S Owen, Calum T Roberts, Ian M R Wright, Peter G Davis, Gaston Arnolda and the Australian and New Zealand Neonatal network (ANZNN)

    This manuscript reports the use of non-invasive ventilation (NIV) in term infants in Australia from 2010 - 2018. The use of NIV increased on average 9% per year. There was an associated increase in the rate of pneumothorax and surfactant use over the same period.

April 08, 2022

  • Original research
    SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants
    Louise Makarious, Arthur Teng, Ju Lee Oei

    This meta-analyses of 4,238,685 children from high-income countries found that while prenatal exposure to any drugs of dependency increased SIDS risk this was greatest for infants prenatally exposed to opioids and methadone. Further research to examine associations in low- and middle-income countries is needed.

April 06, 2022

March 31, 2022

March 14, 2022

March 10, 2022

  • Original research
    Time to positivity of blood cultures in neonatal late-onset bacteraemia
    Sagori Mukhopadhyay, Sara M Briker, Dustin D Flannery, Miren B Dhudasia, Sarah A Coggins, Emily Woodford, Eileen M Walsh, Sherian Li, Karen M Puopolo, Michael W Kuzniewicz

    In a large retrospective cohort study, most blood cultures drawn after 72 hours for suspected bacteremia and not coagulase negative staphylococcus, were reported positive by 36 hours.

March 01, 2022