Online First

June 11, 2021

  • Original research
    Hypotension in Preterm Infants (HIP) randomised trial
    Eugene M Dempsey, Keith J Barrington, Neil Marlow, Colm Patrick Finbarr O'Donnell, Jan Miletin, Gunnar Naulaers, Po-Yin Cheung, John David Corcoran, Afif Faisal EL-Khuffash, Geraldine B Boylan, Vicki Livingstone, Gerard Pons, Jozef Macko, David Van Laere, Hana Wiedermannova, Zbyněk Straňák On behalf of the HIP consortium

    This multicentre double blind randomised trial of restricting the use of dopamine for treatment of hypotensive extremely preterm infants was stopped after recruitment of 8% of the planned sample size. No difference in rates of survival free of severe brain injury was found.

June 10, 2021

June 09, 2021

  • Original research
    Aqueous chlorhexidine 1% versus 2% for neonatal skin antisepsis: a randomised non-inferiority trial
    Akash Sharma, Srikant Kulkarni, Anu Thukral, M Jeeva Sankar, Ramesh Agarwal, A K Deorari, Sarita Mohapatra, Thirumurthy Velpandian, Minu Bajpai

    This controlled trial tested different strengths of aqueous chlorhexidine for neonatal skin antisepsis prior to intravenous cannulation in a neonatal intensive care unit in India, finding that 1% chlorhexidine was effective, but not clearly equivalent to 2% which pending further research remains the recommended concentration for this purpose.

  • Original research
    Effect of breathing on venous return during delayed cord clamping: an observational study
    Emma Brouwer, Ronny Knol, Annie Kroushev, Thomas Van Den Akker, Stuart B Hooper, Arno A Roest, Arjan B te Pas

    Real-time echocardiographic monitoring of blood flow in the ductus venosus and hepatic vein was undertaken during perinatal transition with intact umbilical cord of term born infants. Antegrade flow increased during inspiration, preferentially directing blood flow from the ductus venosus into the right atrium.

June 03, 2021

May 27, 2021

May 26, 2021

May 21, 2021

  • Original research
    Neuronal exosome proteins: novel biomarkers for predicting neonatal response to therapeutic hypothermia
    Beth Pineles, Arunmani Mani, Livia Sura, Candace Rossignol, Mehmet Albayram, Michael David Weiss, Laura Goetzl

    In an observational cohort study, exosome based central nervous system biomarkers from peripheral blood in newborns less than 12 hours old undergoing hypothermia for hypoxic-ischemic encephalopathy differentiated those with favorable and unfavorable MRI injury scores at 5-7 days.

May 20, 2021

May 14, 2021

  • Original research
    Early lung ultrasound affords little to the prediction of bronchopulmonary dysplasia
    Patricia Lee Woods, Benjamin Stoecklin, Amanda Woods, Andrew William Gill

    These investigators report a prospective analysis of preterm babies < 28 weeks gestation in whom lung ultrasounds were performed on a scheduled basis. They found that u/s was predictive in univariate analysis of the development of BPD, but added little to the predictive value when gestational age was included in the model.

  • Original research
    Neonatal arterial stroke location is associated with outcome at 2 years: a voxel-based lesion-symptom mapping study
    Christian Núñez, Christian Stephan-Otto, Gemma Arca, Thais Agut, Juan Arnaez, Malaika Cordeiro, Isabel Benavente-Fernández, Nuria Boronat, Simón Pedro Lubián-López, Eva Valverde, Montesclaros Hortigüela, Alfredo García-Alix

    In a prospective observational multicenter study of neonatal stroke, lesion location identified by MRI is associated with language, motor, and cognitive outcomes at two years of age.

  • Short report
    Nasal expression of SARS-CoV-2 entry receptors in newborns
    Santtu Heinonen, Otto Helve, Sture Andersson, Cecilia Janér, Liina Süvari, Anu Kaskinen

    Low nasal expression of SARS-CoV-2 entry receptors in newborns in both preterm and term cases may contribute to the low attack rates and mild disease in newborns.

May 10, 2021

May 07, 2021

May 06, 2021

  • Original research
    Intrapartum group B Streptococcal prophylaxis and childhood weight gain
    Sagori Mukhopadhyay, Matthew Bryan, Miren B Dhudasia, William Quarshie, Jeffrey S Gerber, Robert W Grundmeier, Corinna Koebnick, Margo A Sidell, Darios Getahun, Andrea J Sharma, Michael W Spiller, Stephanie J Schrag, Karen Marie Puopolo

    Retrospective study of a large cohort of term babies followed up for 5 years. Just under a fifth (17%) of these babies were exposed to antibiotics given to the mother for GBS prophylaxis and these had elevated weight gain in the first 5 yrs. The authors suggest alteration of microbiome as a possible mechanism.

May 05, 2021

April 30, 2021

April 29, 2021

April 27, 2021

April 22, 2021

  • Original research
    Usefulness of video recordings for validating neonatal encephalopathy exams: a population-based cohort study
    Juan Arnaez, Cristina Vega-Del-Val, Montesclaros Hortigüela, Isabel Benavente-Fernández, Miriam Martínez-Biarge, Carlos Ochoa Sangrador, Alfredo Garcia-Alix IC-HIE Study Group

    This manuscript assesses the use of video recordings in a prospective cohort of babies with HIE compared to the neurological assessments by the on site attending physician. There were some discrepancies, especially in babies with mild HIE, but the data support the use of telemedicine to assess HIE severity.

April 21, 2021

  • Review
    Safe emergency neonatal airway management: current challenges and potential approaches
    Joyce E O'Shea, Alexandra Scrivens, Gemma Edwards, Charles Christoph Roehr

    This review describes the challenges encountered with neonatal intubation, particularly in relation to training and achieving competency. It discusses strategies to optimise intubation success and examines the airway adjuncts currently available to manage the neonatal airway.

April 20, 2021

April 19, 2021

  • Original research
    Can EEG accurately predict 2-year neurodevelopmental outcome for preterm infants?
    Rhodri O Lloyd, John M O'Toole, Vicki Livingstone, Peter M Filan, Geraldine B Boylan

    Prospective single centre study of the use of EEG (at 3 gestational ages 72 hours after birth, 32 and 35 weeks corrected) to predict outcome in 57 preterm infants. the study suggest that EEG at 35 weeks is a predictor of outcome at 2years.

April 16, 2021

April 13, 2021

March 31, 2021

  • Original research
    Osteopathic manipulative treatment to improve exclusive breast feeding at 1 month
    Marie Danielo Jouhier, Cécile Boscher, Jean-Christophe Roze, Nicolas Cailleau, Frédéric Chaligne, Arnaud Legrand, Cyril Flamant, Jean-Baptiste Muller NEOSTEO osteopath study group

    This single centre RCT of 128 mother/infant dyads experiencing breast feeding difficulties showed that early osteopathic manipulative treatment did not improve exclusive breast-feeding rates at one month.

  • Original research
    Total body water in full-term and preterm newborns: systematic review and meta-analysis
    Aneurin Young, Lisa K Brown, Sarah Ennis, R Mark Beattie, Mark John Johnson

    This systematic review identified 22 eligible trials and confirmed that the proportion of total body water at birth falls with increasing gestational age, from 90% at 26 weeks’ gestation to 74% at term.

March 11, 2021

  • Original research
    Thermal management with and without servo-controlled system in preterm infants immediately after birth: a multicentre, randomised controlled study
    Francesco Cavallin, Nicoletta Doglioni, Alessandra Allodi, Nadia Battajon, Stefania Vedovato, Letizia Capasso, Eloisa Gitto, Nicola Laforgia, Giulia Paviotti, Maria Grazia Capretti, Camilla Gizzi, Paolo Ernesto Villani, Paolo Biban, Simone Pratesi, Gianluca Lista, Fabrizio Ciralli, Massimo Soffiati, Alex Staffler, Eugenio Baraldi, Daniele Trevisanuto on behalf of Servo COntrol for PReterm Infants (SCOPRI) Trial Group

    This multicentre double blind RCT of 450 preterm infants evaluated the effectiveness of a thermal servo-controlled system in the delivery room. There was no important difference in rates of normothermia but the servo-controlled system was associated with increased mild hypothermia.

March 09, 2021

  • Original research
    Randomised trial of epinephrine dose and flush volume in term newborn lambs
    Deepika Sankaran, Praveen K Chandrasekharan, Sylvia F Gugino, Carmon Koenigsknecht, Justin Helman, Jayasree Nair, Bobby Mathew, Munmun Rawat, Payam Vali, Lori Nielsen, Daniel J Tancredi, Satyan Lakshminrusimha

    In newborn lambs with cardiac arrest, higher doses of adrenaline and larger flush volumes were more effective in achieving return of spontaneous circulation during cardiopulmonary resuscitation.

March 08, 2021

March 03, 2021