Online First

November 24, 2022

November 23, 2022

November 18, 2022

November 17, 2022

November 15, 2022

November 09, 2022

  • Original research
    Immunoreactive trypsinogen in healthy newborns and infants with cystic fibrosis
    Ralph Fingerhut, Corina Silvia Rueegg, Orell Imahorn, Eva Sophie Lunde Pedersen, Claudia Elisabeth Kuehni, Sabina Gallati, Nicolas Regamey, Jürg Barben

    Newborn screening programmes for cystic fibrosis (CF) are based on levels of immuno-reactive trypsinogen (IRT). This study highlights the importance of gestational age and day of sampling in interpreting these results and emphasises the importance of a second IRT for inconclusive diagnoses.

November 07, 2022

November 03, 2022

October 28, 2022

October 21, 2022

October 19, 2022

  • Original research
    Do newborn infants exhale through the CPAP system? Secondary analysis of a randomised cross-over trial
    Kolbrun Gunnarsdottir, Markus Falk, Sonja Baldursdottir, Snorri Donaldsson, Baldvin Jonsson, Thomas Drevhammar

    In this study, investigators demonstrate for the first time that newborns receiving low levels of CPAP pressure are able to exhale through the CPAP circuit.

  • Original research
    Views of parents, adults born preterm and professionals on linkage of real-world data of preterm babies
    Mary Sawtell, Emily van Blankenstein, Tahira Bilal, Taralise Hall, Lisa Juniper, Julia Kotsoni, Juliette Lee, Neena Modi, Cheryl Battersby

    In a mixed methods approach involving focus groups, interviews, and a national survey, this study found that parents, adults born preterm, and professionals are supportive of routine linkage of health and education data for research focused on improving outcomes.

  • Original research
    Predicting the likelihood of lower respiratory tract Ureaplasma infection in preterms
    Rose Marie Viscardi, Laurence S Magder, Michael L Terrin, Natalie L Davis

    Predictive models to determine the likelihood of lower respiratory tract Ureaplasma infection were developed based on perinatal clinical information available.These models may be useful in the design of clinical trials of therapeutic interventions to prevent Ureaplasma-mediated BPD.

October 17, 2022

October 12, 2022

  • Original research
    Diaphragm electrical activity during weaning of nasal high-flow therapy in preterm infants
    Rebecca Naples, Alan C Fenton, Malcolm Brodlie, Sundeep Harigopal, Chris O'Brien

    Investigators in this manuscript examined electrical activity of the diaphragm (Edi) in 40 preterm infants during pre-specified weaning of high flow nasal cannula. Edi significantly increased only after the final wean from 2L/min of flow, suggesting increased work of breathing.

October 07, 2022

  • Review
    Diversity and trends of human milk banking: a scoping review from 1946 to 2021
    Linda P Siziba, Sebastian Huhn, Elisabeth Pütz, Caroline Baier, Raphael S Peter, Corinna Gebauer, Samantha Griffin, Sophie Wedekind, Natalie Shenker, Jon Genuneit

    This scoping review describes the published information on banked donor human milk and highlights areas for future research and increased access.

September 29, 2022

September 27, 2022

  • Original research
    Management of pneumothorax in neonatal retrieval: a retrospective cohort study
    Ikhwan Halibullah, Fiona Hammond, Kate Hodgson, Natalie Duffy, Michael Stewart, Arun Sett

    In a small retrospective cohort study of infants with pneumothorax, incidence of deterioration and need for an intercostal catheter was low during transport without an intercostal catheter.

September 26, 2022

September 14, 2022

September 06, 2022

  • Original research
    Sociodemographic risk factors, parental stress and social support in the neonatal intensive care unit
    Tamiko Younge, Marni Jacobs, Lisa Tuchman, Randi Streisand, Lamia Soghier, Karen Fratantoni

    This research emphasises the importance of the role of social support in modifying the effects of parent experiences of stress in the NICU at the time of discharge. The study shows that socio-demographic risk factors may not infer stress or risk in the anticipated direction: here, higher education and socio-economic status were associated with greater parental stress. Additionally, lower socioeconomic status, though associated with decreased social support, did not infer greater stress.

September 05, 2022

August 29, 2022

  • Original research
    Lung volume changes during apnoeas in preterm infants
    Vincent D Gaertner, Andreas D Waldmann, Peter G Davis, Dirk Bassler, Laila Springer, David Gerald Tingay, Christoph Martin Rüegger

    Well-done study comparing end-expiratory lung volumes during apneas using EIT during nasal support via nCPAP vs. nHFOV in 30 infants. They found that lung volume decreased less during apnea while on nHFOV than during CPAP, and SpO2 was more stable.

  • Original research
    Caffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial
    Elizabeth Anne Oliphant, Christopher JD McKinlay, David McNamara, Alana Cavadino, Jane M Alsweiler

    In late preterms (132 infants, 34-36 weeks), a randomized controlled trial (placebo, versus different caffeine citrate doses), caffeine reduces intermittent hypoxia events at 2 weeks of age, with 20 being the most effective dose.

August 25, 2022

  • Original research
    Growth trajectory during the first 1000 days and later overweight in very preterm infants
    Laure Simon, Alice Hadchouel, Catherine Arnaud, Anne Frondas-Chauty, Stéphane Marret, Cyril Flamant, Dominique Darmaun, Christophe Delacourt, Laetitia Marchand-Martin, Pierre Yves Ancel, Jean-Christophe Roze

    Former very preterm born children that are overweight, underweight or normal at 5 or 15 years already had significant different BMI Z-scores by 2 years of age. Change in length Z-score during NICU stay might have a protective effect against later overweight or obesity.

  • Original research
    Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study
    Carlos Zozaya, Niloofar Ganji, Bo Li, Maarten Janssen Lok, Carol Lee, Yuhki Koike, Estelle Gauda, Martin Offringa, Simon Eaton, Prakeshkumar S Shah, Agostino Pierro

    In a small phase 1 pilot study in preterm infants with suspected or confirmed necrotizing enterocolitis, cycles of remote ischemic conditioning with short duration of limb ischemia using a sphygmomanometer followed by reperfusion and rest was feasible and safe.

August 23, 2022

  • Original research
    Bronchopulmonary dysplasia and neurobehavioural outcomes at birth and 2 years in infants born before 30 weeks
    Monika Martin, Lynne Smith, Julie A Hofheimer, Elisabeth C McGowan, T Michael O'Shea, Steve Pastyrnak, Brian Scott Carter, Jennifer Helderman, Jennifer Check, Charles Neal, Mary B Roberts, Lynne M Dansereau, Sheri A Della Grotta, Barry M Lester

    In a prospective, multicenter study of infants < 30 weeks GA, BPD severity was associated with neurobehavioral outcomes at the time of hospital discharge as measured by NNNS, and with 2 year outcomes.

  • Original research
    Automatic oxygen control for reducing extremes of oxygen saturation: a randomised controlled trial
    Vrinda Nair, Prakash Kannan Loganathan, Mithilesh Kumar Lal, Helen Pringleton, Thomas Edward Bachman, Malcolm Brodlie, Paul Dixon

    In this randomised controlled trial that included 44 infants, servo controlled adjustment of FiO2 improved oxygen targeting over the duration of ventilation and nasal CPAP treatment.

August 11, 2022

August 08, 2022

August 05, 2022

July 28, 2022

  • Original research
    Early-onset neonatal sepsis in the Paris area: a population-based surveillance study from 2019 to 2021
    Paola Sikias, Valérie Biran, Laurence Foix-L'Hélias, Céline Plainvert, Pascal Boileau, Stéphane Bonacorsi the EOS study group

    This population surveillance study of infants ≥34 weeks' gestation reports the incidence of early-onset sepsis, causative organisms and antibiotic susceptibilities. Details of maternal Group B Streptococcus screening status and prophylactic treatment are provided.

July 18, 2022

July 14, 2022

July 05, 2022

July 04, 2022

June 24, 2022

  • Original research
    Lung ultrasound of the dependent lung detects real-time changes in lung volume in the preterm lamb
    Arun Sett, Kelly R Kenna, Rebecca J Sutton, Elizabeth J Perkins, Magdy Sourial, Jack D Chapman, Susan M Donath, Arun Sasi, Sheryle R Rogerson, Brett J Manley, Peter G Davis, Prue M Pereira-Fantini, David G Tingay

    In preterm newborn lambs, lung ultrasound of the dependent lung was able to detect large changes in total and regional lung volume in real-time and correctly identified opening and closing pressures but lacked the precision to detect small changes in lung volume.

June 22, 2022

June 21, 2022

June 15, 2022

  • Original research
    Acceleration during neonatal transport and its impact on mechanical ventilation
    Lajos Lantos, András Széll, David Chong, Zsolt Somogyvári, Gusztav Belteki

    This study addresses the impact of the neonatal transport environment on mechanical ventilation. The study provides some information on the forces neonates are exposed to during transport and the response of ventilation equipment to this.

  • Original research
    Early-onset sepsis in very preterm neonates in Australia and New Zealand, 2007–2018
    Husharn L Duggan, Sharon S W Chow, Nicola C Austin, Prakeshkumar S Shah, Kei Lui, Kenneth Tan on behalf of the Australian and New Zealand Neonatal Network

    In a retrospective study from the Australian New Zealand Neonatal Network database, incidence of early onset sepsis in infants less than 32 weeks gestation was stable over 12 years, and incidence of e.coli, the predominant organism, increased.

May 26, 2022

May 16, 2022

May 12, 2022