Online First

September 23, 2021

September 22, 2021

  • Original research
    Implementation of an adapted Sepsis Risk Calculator algorithm to reduce antibiotic usage in the management of early onset neonatal sepsis: a multicentre initiative in Wales, UK
    Nitin Goel, Stephanie Cannell, Gemma Davies, Murali Sridhar Natti, Vickness Kirupaalar, Artur Abelian, Shakir Saeed, Rhian Smith, Ravi Manikonda, Prem Kumar Pitchaikani, Dawn Davies, Rachel May Morris, Lynsey Edwards, Roopashree Govindaraju, Kate Creese, Jane Jones, Jalil Choudhary, Sarah Rowley, Chidambaram Sethuraman, Helen Muxworthy, Felicity Curtis, Patricia Donnelly, Manohar Joishy, Ian Barnard, Celyn Kenny, Rajarshi Pal, Karen Jones, Sujoy Banerjee

    Antibiotic use in the newborn may have long lasting impact. Neonatal sepsis is relatively rare but one which causes concern, investigation and treatment. This paper describes the implementation of an sepsis risk calculator to reduce antibiotic use in a safe and sustainable way.

September 21, 2021

September 20, 2021

September 11, 2021

  • Letter
    Impact of the new NICE guidance 2021 on management of early onset neonatal sepsis
    Laura Macaskill, Samantha Slee, Tim J van Hasselt, Muhammed Naseem, Andrew K Ewer, Pinki Surana Paediatric Research Across the Midlands (PRAM) Network
  • Original research
    Mortality and significant neurosensory impairment in preterm infants: an international comparison
    Marie Chevallier, Thierry Debillon, Brian A Darlow, Anne R Synnes, Véronique Pierrat, Elizabeth Hurrion, Junmin Yang, Anne Ego, Pierre Yves Ancel, Kei Lui, Prakeshkumar S Shah, Thuy Mai Luu, Australian and New Zealand Neonatal Network (ANZNN), Canadian Neonatal Network (CNN), Canadian Neonatal Follow-Up Network (CNFUN) Etude Epidémiologique sur les Petits Ages Gestationnels (EPIPAGE-2) Investigators

    The composite outcome of mortality and significant neurodisability in extremely low birth weight infants is compared across 3 different international cohorts (Canada, Australia/New Zealand, France). The composite outcome was higher in the French cohort, driven by a higher mortality.

  • Original research
    SARS-CoV-2 RNA and antibody detection in breast milk from a prospective multicentre study in Spain
    Christine Bäuerl, Walter Randazzo, Gloria Sánchez, Marta Selma-Royo, Elia García Verdevio, Laura Martínez, Anna Parra-Llorca, Carles Lerin, Victoria Fumadó, Francesca Crovetto, Fatima Crispi, Francisco J Pérez-Cano, Gerardo Rodríguez, Gemma Ruiz-Redondo, Cristina Campoy, Cecilia Martínez-Costa, Maria Carmen Collado on behalf of MilkCORONA study team

    ARS-CoV-2 antibodies but not RNA are found in breast milk from COVID-19 infected mothers.

September 07, 2021

September 06, 2021

August 30, 2021

  • Original research
    Neonates with mild hypoxic–ischaemic encephalopathy receiving supportive care versus therapeutic hypothermia in California
    Leah Yieh, Henry Lee, Tianyao Lu, Ashley Song, Cynthia L Gong, Tai-Wei Wu, Philippe Friedlich, Ashwini Lakshmanan, Dmitry Dukhovny, Joel Hay

    This manuscript reports trends in the use of therapeutic hypothermia for babies with mild HIE in the NICUs in the CPQCC catchment, and assesses odds ratios for maternal and infant factors associated with the use of TH. There was an increase in the use of TH for mild HIE increased over time as a form of therapeutic creep.

  • Original research
    Comparison of intraosseous and intravenous epinephrine administration during resuscitation of asphyxiated newborn lambs
    Calum T Roberts, Sarah Klink, Georg M Schmölzer, Douglas A Blank, Shiraz Badurdeen, Kelly J Crossley, Karyn Rodgers, Valerie Zahra, Alison Moxham, Charles Christoph Roehr, Martin Kluckow, Andrew William Gill, Stuart B Hooper, Graeme R Polglase

    When intravenous access is not easily attainable, recommendations are to use intra-osseus as an alternative route for adrenaline administration in neonatal resuscitation. In an non-randomized trial in a lamb model, these two delivery routes were equivalent in terms of success in resuscitation and serum adrenaline levels.

August 25, 2021

August 23, 2021

August 19, 2021

August 04, 2021

August 03, 2021

  • Original research
    Monitoring of carbon dioxide in ventilated neonates: a prospective observational study
    Tobias Werther, Lukas Aichhorn, Sina Stellberg, Francesco Stefano Cardona, Katrin Klebermass-Schrehof, Angelika Berger, Georg M Schmölzer, Michael Wagner

    This study comparing the precision and accuracy of end-tidal and transcutaneous pCO2 with arterial measurements found that end-tidal CO2, measured through a double-lumen ET tube in ventilated neonates, was superior to tcpCO2.

August 02, 2021

July 30, 2021

July 29, 2021

July 28, 2021

  • Original research
    Temporal trends in respiratory care and bronchopulmonary dysplasia in very preterm infants over a 10-year period in Spain
    Alejandro Avila-Alvarez, Carlos Zozaya, Sonia Pértega-Diaz, Manuel Sanchez-Luna, Martin Iriondo-Sanz, Maria Dolores Elorza, Fermín García-Muñoz Rodrigo Spanish Neonatal Network SEN1500

    National survey of changes in respiratory outcomes of VLBW infants over 2 periods, showing that outcome did not improve despite an increase in the use of non-invasive ventilation.

  • Original research
    Oesophageal atresia: sonographic signs may prenatally predict surgical complexity
    Tal Weissbach, Anya Kushnir, Ella Haber Kaptsenel, Leah Leibovitch, Ron Bilik, Daniel Shinhar, Gideon Karplus, Reuven Achiron, Zvi Kivilevitch, Eran Barzilay, Shali Mazaki Tovi, Boaz Weisz, Eran Kassif

    This manuscript characterizes prenatal ultrasound findings of babies with esophageal atresia with the presence or absence of a distal fistula. The authors found several ultrasound parameters were correlated with more complex repair and absence of a distal fistula

  • Original research
    Direct swallowing training and oral sensorimotor stimulation in preterm infants: a randomised controlled trial
    Ju Sun Heo, Ee-Kyung Kim, Sae Yun Kim, In Gyu Song, Young Mi Yoon, Hannah Cho, Eun Sun Lee, Seung Han Shin, Byung-Mo Oh, Hyung-Ik Shin, Han-Suk Kim

    This single centre, masked RCT enrolling 186 infants <32 weeks gestation found that direct swallowing training combined with oral sensorimotor stimulation significantly shortened the time to independent oral feeding compared with no intervention.

July 19, 2021

July 14, 2021

July 13, 2021

  • Original research
    Growth in extremely preterm children born in England in 1995 and 2006: the EPICure studies
    Yanyan Ni, Rebecca Lancaster, Emmi Suonpera, Marialivia Bernardi, Amanda Fahy, Jennifer Larsen, Jayne Trickett, John R Hurst, Dieter Wolke, Samantha Johnson, Neil Marlow

    This paper describes the growth to age 11 of a sample of the EPICure 2 2006 preterm birth cohort, compared to healthy same age controls and to the 1995 EPICure cohort. Since 1995, childhood growth in weight, height and BMI have improved for births <26 weeks of gestation, but there was no improvement in head growth.

  • Original research
    Titres and neutralising capacity of SARS-CoV-2-specific antibodies in human milk: a systematic review
    Jia Ming Low, Yue Wey Low, Youjia Zhong, Cheuk Yiu Charlotte Lee, Ming Chan, Nicholas Beng Hui Ng, Zubair Amin, Yvonne Peng Mei Ng

    Systematic review on the titers and neutralising capacity of SARS-CoV-2-specific antibodies in human milk demonstrates that these antibodies can neutralise the virus in vitro. Furthermore, high pressure, but not Holder pasteurisation deactivates the specific IgAs.

  • Short report
    Discriminating necrotising enterocolitis and focal intestinal perforation
    Janet Berrington, Nicholas D Embleton

July 07, 2021

June 29, 2021

June 28, 2021

  • Original research
    Life-threatening bronchopulmonary dysplasia: a British Paediatric Surveillance Unit Study
    Rebecca Naples, Sridhar Ramaiah, Judith Rankin, Janet Berrington, Sundeep Harigopal

    The authors describe a prospective cohort of 153 babies with "life threatening BPD" defined as requiring positive pressure at 38 weeks corrected gestational age. Data were collected from the British Paediatric Surveillance Unit from June 2017 to July 2018. Findings include a high likelihood of serious morbidity and mortality, and large practice variation in therapies.

June 25, 2021

June 23, 2021

  • Original research
    Extubation generates lung volume inhomogeneity in preterm infants
    Risha Bhatia, Hazel R Carlisle, Ruth K Armstrong, C Omar Farouk Kamlin, Peter G Davis, David G Tingay

    Observational study using Electrical Impedance Tomography to confirm that lung volume is lost during transition from IPPV to CPAP.

  • Original research
    Parent-reported health status of preterm survivors in a Canadian cohort
    Satvinder Ghotra, David Feeny, Ronald Barr, Junmin Yang, Saroj Saigal, Michael Vincer, Jehier Afifi, Prakeshkumar S Shah, Shoo K Lee, Anne R Synnes Canadian Neonatal Follow-Up Network Investigators

    Among infants <29 weeks' gestation in the Canadian Neonatal Follow Up Network with parent-reported health status impact at 36 months, most reported none or mild concerns, and only ~ 1 in 4 reported moderate or severe concerns. Concerns were associated with a range of factors.

June 18, 2021

June 15, 2021