Article Text

Download PDFPDF
Unnatural selection: reducing antibiotic resistance in neonatal units
  1. D Isaacs
  1. Correspondence to:
    Dr Isaacs
    Department of Allergy, Immunology & Infectious Diseases, Children’s Hospital at Westmead, Westmead, Sydney, 2122, NSW, Australia; davidi{at}


Antibiotic use selects for antibiotic resistant bacteria. This is an example of rapid Darwinian natural selection in action. It occurs in neonatal intensive care units with the use of parenteral antibiotics, and in the community with oral antibiotic use. A 10 point plan is put forward to reduce antibiotic resistance in neonatal units.

  • infection
  • extended spectrum β lactamases
  • antibiotic resistance
  • Klebsiella

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests: none declared