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Measurement of interleukin 10 in bronchoalveolar lavage from preterm ventilated infants
  1. Janet R McColm,
  2. Ben J Stenson,
  3. Nienke Biermasz,
  4. Neil McIntosh
  1. Child Life and Health, Reproductive Medicine and Developmental Sciences, University of Edinburgh, 20 Sylvan Place, Edinburgh EH9 1UW, UK
  1. Dr McColm


BACKGROUND Interleukin 10 (IL-10) is a cytokine that downregulates inflammation, in part by reducing the production of the proinflammatory cytokines IL-1β and IL-8. It has been suggested that an inability to produce IL-10 might predispose preterm infants to develop chronic lung disease.

AIM To measure IL-10, IL-1β, and IL-8 in bronchoalveolar lavage fluid from ventilated preterm infants in a prospective cohort study.

PATIENTS 17 consecutive newborn infants ⩽ 29 weeks' gestational age (median, 25; 9 boys) who were ventilated from birth underwent daily bronchoalveolar lavage sampling.

RESULTS 102 samples were collected, of which 57 contained IL-10 in amounts that were comparable with those found previously in ventilated term infants with respiratory failure. Chronic lung disease developed in 9 of the 11 survivors and all 9 infants had produced IL-10. IL-1β and IL-8 were detected in nearly all samples and were raised throughout the course of sample collection.

CONCLUSION IL-10 is readily detectable in early bronchoalveolar lavage samples from ventilated preterm infants, although it remains unclear whether this cytokine has any influence on the development of chronic lung disease.

  • inflammation
  • cytokines
  • bronchopulmonary dysplasia
  • chronic lung disease
  • very preterm infants

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