Objective To determine the association between SpO₂ at 5 min and preterm infant outcomes.

Design Data from 768 infants <32 weeks gestation from 8 randomised controlled trials (RCTs) of lower (≤0.3) versus higher (≥0.6) initial inspiratory fractions of oxygen (FiO₂) for resuscitation, were examined.

Setting Individual patient analysis of 8 RCTs

Interventions Lower (≤0.3) versus higher (≥0.6) oxygen resuscitation strategies targeted to specific predefined SpO₂ before 10 min of age.

Patients Infants <32 weeks gestation.

Main outcome measures Relationship between SpO₂ at 5 min, death and intraventricular haemorrhage (IVH) >grade 3.

Results 5 min SpO₂ data were obtained from 706 (92%) infants. Only 159 (23%) infants met SpO₂ study targets and 323 (46%) did not reach SpO₂80%. Pooled data showed decreased likelihood of reaching SpO₂80% if resuscitation was initiated with FiO₂ <0.3 (OR 2.63, 95% CI 1.21 to 5.74, p<0.05). SpO₂ <80% was associated with lower heart rates (mean difference −8.37, 95% CI −15.73 to –1.01, *p<0.05) and after accounting for confounders, with IVH (OR 2.04, 95% CI 1.01 to 4.11, p<0.05). Bradycardia (heart rate <100 bpm) at 5 min increased risk of death (OR 4.57, 95% CI 1.62 to 13.98, p<0.05). Taking into account confounders including gestation, birth weight and 5 min bradycardia, risk of death was significantly increased with time taken to reach SpO₂80%.

Conclusion Not reaching SpO₂80% at 5 min is associated with adverse outcomes, including IVH. Whether this is because of infant illness or the amount of oxygen that is administered during stabilisation is uncertain and needs to be examined in randomised trials