Down’s syndrome (DS), caused by trisomy of human chromosome 21, is the most common
genetic cause of intellectual disability. Here we use induced pluripotent stem cells (iPSCs) …

Human pluripotent stem cells (hPSCs) have been differentiated to astroglia, but the utilization
of hPSC-derived astroglia as cell therapy for neurological diseases has not been well …

The lack of robust treatment options available for neurodegenerative diseases, stroke, and
central nervous system (CNS) trauma, all of which often involve both inflammation and …

Periventricular leukomalacia (PVL) is the predominant form of brain injury and the leading
known cause of cerebral palsy and cognitive deficits in premature infants. The number of low-…

Hypoxic–ischemic brain injury in premature infants results in cerebral white matter lesions
with prominent oligodendroglial injury and loss, a disorder termed periventricular …

Periventricular leukomalacia is a form of hypoxic–ischemic cerebral white matter injury seen
most commonly in premature infants and is the major antecedent of cerebral palsy. …

Stimuli-responsive cross-linked micelles (SCMs) represent an ideal nanocarrier system for
drug delivery against cancers. SCMs exhibit superior structural stability compared to their non-…

Molecular events that regulate cellular biosynthesis of steroid hormones have been a topic
of intense research for more than half a century. It has been established that transport of …

Recent studies demonstrate that astroglial cells can be directly converted into functional
neurons or oligodendrocytes. Here, we report that a single transcription factor Sox10 could …

Objective Thrombin mediates the life‐threatening cerebral edema that occurs after intracerebral
hemorrhage. Therefore, we examined the mechanisms of thrombin‐induced injury to the …