User profiles for H Uno

Hajime Uno

Dana-Farber Cancer Institute/Havard Medical School
Verified email at ds.dfci.harvard.edu
Cited by 12411

Neurotoxicity of glucocorticoids in the primate brain

H Uno, S Eisele, A Sakai, S Shelton, E Baker… - Hormones and …, 1994 - Elsevier
Severe and prolonged physical and psychological stress is known to cause brain damage;
long-term torture victims in prison bare later developed psychiatric disorders and cerebral …

GEANT4—a simulation toolkit

…, ES Tehrani, M Tropeano, P Truscott, H Uno… - Nuclear instruments and …, 2003 - Elsevier
Geant4 is a toolkit for simulating the passage of particles through matter. It includes a complete
range of functionality including tracking, geometry, physics models and hits. The physics …

Adaptive management of sika deer populations in Hokkaido, Japan: theory and practice

K Kaji, T Saitoh, H Uno, H Matsuda, K Yamamura - Population Ecology, 2010 - Springer
We investigated the utility of adaptive management (AM) in wildlife management, reviewing
our experiences in applying AM to overabundant sika deer (Cervus nippon) populations in …

Estimation of rock mass deformation modulus and strength of jointed hard rock masses using the GSI system

M Cai, PK Kaiser, H Uno, Y Tasaka… - International Journal of …, 2004 - Elsevier
Rock mass characterization is required for many applications in rock engineering practice
including excavation design, support design, stope design, amongst others. For these …

Hippocampal damage associated with prolonged glucocorticoid exposure in primates

RM Sapolsky, H Uno, CS Rebert… - Journal of …, 1990 - Soc Neuroscience
In the laboratory rat and guinea pig, glucocorticoids (GCs), the adrenal steroids that are secreted
during stress, can damage the hippocampus and exacerbate the hippocampal damage …

On the C‐statistics for evaluating overall adequacy of risk prediction procedures with censored survival data

H Uno, T Cai, MJ Pencina, RB D'Agostino… - Statistics in …, 2011 - Wiley Online Library
For modern evidence‐based medicine, a well thought‐out risk scoring system for predicting
the occurrence of a clinical event plays an important role in selecting prevention and …

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

T Davoli, H Uno, EC Wooten, SJ Elledge - Science, 2017 - science.org
INTRODUCTION Aneuploidy, also known as somatic copy number alterations (SCNAs), is
widespread in human cancers and has been proposed to drive tumorigenesis. The …

Hippocampal damage associated with prolonged and fatal stress in primates

H Uno, R Tarara, JG Else, MA Suleman… - Journal of …, 1989 - Soc Neuroscience
Sustained exposure to glucocorticoids (GCs), adrenal hormones secreted during stress, can
cause neural degeneration in the rat. This is particularly so in the hippocampus, a principal …

[HTML][HTML] Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis

H Uno, B Claggett, L Tian, E Inoue, P Gallo… - Journal of clinical …, 2014 - ncbi.nlm.nih.gov
In a longitudinal clinical study to compare two groups, the primary end point is often the time
to a specific event (eg, disease progression, death). The hazard ratio estimate is routinely …

Merkel cells and Merkel cell tumors ultrastructure, immunocytochemistry and review of the literature

TFCS Warner, H Uno, GR Hafez, J Burgess, C Bolles… - Cancer, 1983 - Wiley Online Library
… , possibly due to a focal degeneration of tumor cells (H & E, X300). (B, center) An alveolar
pattern is created by growth of tumor cells along delicate fibrous septae (H & E, X300). (C, right…