[HTML][HTML] Mesenchymal stromal cells as a potential therapeutic for neurological disorders

T Mukai, A Tojo, T Nagamura-Inoue - Regenerative therapy, 2018 - Elsevier
Several studies have reported that mesenchymal stromal/stem cells (MSCs) restore
neurological damage through their secretion of paracrine factors or their differentiation to …

Cell Therapies for Autism Spectrum Disorder Based on New Pathophysiology: A Review

M Nabetani, T Mukai, A Taguchi - Cell Transplantation, 2023 - journals.sagepub.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by difficulties in social communication, repetitive behaviors, and restricted interests, with …

Umbilical cord is a rich source of mesenchymal stromal cells for cell therapy

T Nagamura-Inoue, T Mukai - Current stem cell research & …, 2016 - ingentaconnect.com
Recently, umbilical cord (UC) and UC-derived mesenchymal stromal cells (UC-MSCs) have
attracted much attention for many reasons, including (1) abundant sources and ease of …

[HTML][HTML] Aggravated brain injury after neonatal hypoxic ischemia in microglia-depleted mice

S Tsuji, E Di Martino, T Mukai, S Tsuji… - Journal of …, 2020 - Springer
Background Neuroinflammation plays an important role in neonatal hypoxic-ischemic
encephalopathy (HIE). Although microglia are largely responsible for injury-induced …

Intravenous injection of umbilical cord-derived mesenchymal stromal cells attenuates reactive gliosis and hypomyelination in a neonatal intraventricular hemorrhage …

T Mukai, Y Mori, T Shimazu, A Takahashi, H Tsunoda… - Neuroscience, 2017 - Elsevier
Intraventricular hemorrhage (IVH) is a frequent complication of preterm newborns, resulting
in cerebral palsy and cognitive handicap as well as hypoxic ischemic encephalopathy and …

[HTML][HTML] Dose-dependent effect of intravenous administration of human umbilical cord-derived mesenchymal stem cells in neonatal stroke mice

E Tanaka, Y Ogawa, T Mukai, Y Sato… - Frontiers in …, 2018 - frontiersin.org
Neonatal brain injury induced by stroke causes significant disability, including cerebral
palsy, and there is no effective therapy for stroke. Recently, mesenchymal stem cells (MSCs) …

[HTML][HTML] Therapeutic hypothermia for neonatal encephalopathy: a report from the first 3 years of the Baby Cooling Registry of Japan

K Tsuda, T Mukai, S Iwata, J Shibasaki, T Tokuhisa… - Scientific reports, 2017 - nature.com
Therapeutic hypothermia is recommended for moderate and severe neonatal
encephalopathy, but is being applied to a wider range of neonates than originally …

[HTML][HTML] The immunomodulatory effect of triptolide on mesenchymal stromal cells

H He, A Takahashi, T Mukai, A Hori, M Narita… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are known to have immunosuppressive ability and have
been used in clinical treatment of acute graft-versus-host disease, one of severe …

[HTML][HTML] Umbilical cord-derived mesenchymal stromal cells contribute to neuroprotection in neonatal cortical neurons damaged by oxygen-glucose deprivation

T Mukai, A Tojo, T Nagamura-Inoue - Frontiers in Neurology, 2018 - frontiersin.org
Several studies have reported that human umbilical cord-derived mesenchymal stromal
cells (UC-MSCs) restore neurological damage in vivo through their secretion of paracrine …

Neurosphere formation enhances the neurogenic differentiation potential and migratory ability of umbilical cord-mesenchymal stromal cells

T Mukai, T Nagamura-Inoue, T Shimazu, Y Mori… - Cytotherapy, 2016 - Elsevier
Background aims The human umbilical cord (UC) is a rich source of mesenchymal stromal
cells (MSCs), which have been reported to have multi-lineage potential. The objectives of …