Certain dietary antioxidants such as vitamin E and vitamin C are important for maintaining
optimum health. There is now much interest in polyphenolic products of the plant …

The comet assay is a versatile method to detect nuclear DNA damage in individual
eukaryotic cells, from yeast to human. The types of damage detected encompass DNA …

Folic acid deficiency in humans has been linked with megaloblastic anaemia, neural tube
defects in the neonate, and heart disease. Folate has also been implicated in the …

The endogenous production of oxidative damage in DNA by free radicals released as a by-
product of respiration is a likely cause of mutations which, if they occur in appropriate genes …

Single cell gel electrophoresis is a sensitive method for detecting DNA strand breaks. Cells
embedded in agarose are converted to nucleoids by treating with detergent and high salt …

The association between high intake of fruit and vegetables and low incidence of certain
cancers is well established. Dietary antioxidants present in these foods are thought to …

Background Consumption of fruit and vegetables is associated with a decreased risk of
heart disease and cancer. This has been ascribed in part to antioxidants in these foods …

Anthocyanins are secondary plant metabolites responsible for the blue, purple, and red
color of many plant tissues. The phenolic structure of anthocyanins conveys marked …

Folic acid is essential for the synthesis and repair of DNA. We report the effects of folate
depletion on DNA stability in normal human lymphocytes in vitro. DNA strand breakage …

Convincing evidence links folate deficiency with colorectal cancer incidence. Currently, it is
believed that folate deficiency affects DNA stability principally through two potential …