Dunne, Mark J., Karen E. Cosgrove, Ruth M. Shepherd, Albert Aynsley-Green, and Keith J.
Lindley. Hyperinsulinism in Infancy: From Basic Science to Clinical Disease. Physiol Rev 84 …

Usher syndrome type 1 describes the association of profound, congenital sensorineural
deafness, vestibular hypofunction and childhood onset retinitis pigmentosa 1. It is an …

It is often assumed, but has not been demonstrated, that the oscillations of cytoplasmic
calcium (Ca2+ i) that occur in various secretory cells induce oscillations in secretion. Here …

Persistent hyperinsulinemic hypoglycemia of infancy is caused by inappropriate and
excessive secretion of insulin. Although the disease is rare in outbred communities …

Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is a disorder of childhood
associated with inappropriate hypersecretion of insulin by the pancreas. The pathogenesis …

Because glucokinase is a metabolic sensor involved in the regulated release of insulin, we
have investigated the acute actions of novel glucokinase activator compound 50 (GKA50) on …

Clinical profiles of the glucose regulation disorders persistent hyperinsulinaemic
hypoglycaemia of infancy (PHHI) and diabetes mellitus are diametrically opposed …

Background Human embryonic stem cells (HESC) readily differentiate into an apparently
haphazard array of cell types, corresponding to all three germ layers, when their culture …

Insulin is synthesised, stored, and secreted from pancreatic β cells. These are located within
the islets of Langerhans, which are distributed throughout the pancreas. Less than 2% of the …

Glucose regulates insulin production in pancreatic beta-cells in the long term by stimulating
insulin gene transcription. These effects are partially mediated through the activity of a …