Usher syndrome type 1 describes the association of profound, congenital sensorineural
deafness, vestibular hypofunction and childhood onset retinitis pigmentosa 1. It is an …

Insulin is synthesised, stored, and secreted from pancreatic β cells. These are located within
the islets of Langerhans, which are distributed throughout the pancreas. Less than 2% of the …

Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is a neonatal disease
characterized by dysregulation of insulin secretion accompanied by profound hypoglycemia …

Hyperinsulinism of infancy (HI) is a congenital defect in the regulated release of insulin from
pancreatic β-cells. Here we describe stimulus-secretion coupling mechanisms in β-cells and …

A novel ATP-sensitive potassium channel (KATP) channel agonist, BPDZ 154 (6, 7-dichloro-
3-isopropylamino-4 H-1, 2, 4-benzothiadiazine 1, 1-dioxide), was synthesized, and its effects …

Synthesis and characterization of a quinolinonic compound activating ATP-sensitive K+
channels in endocrine and smooth muscle tissues - PMC Back to Top Skip to main content NIH …

NES2Y is a proliferating human insulin-secreting cell line that we have derived from a
patient with persistent hyperinsulinemic hypoglycemia of infancy. This disease is …

The effect of Y-26763 [(−)-(3S, 4R)-4-(N-acetyl-N-hydroxyamino)-6-cyano-3, 4-dihydro-2, 2-
dimethyl-2H-1-benzopyran-3-ol], a novel ATP-sensitive K+ (KATP) channel activator, was …

Hyperinsulinism of infancy (HI) is a congenital defect in the regulated release of insulin from
pancreatic β-cells. Here we describe stimulus-secretion coupling mechanisms in β-cells and …