The cancer genome
MR Stratton, PJ Campbell, PA Futreal - Nature, 2009 - nature.com
All cancers arise as a result of changes that have occurred in the DNA sequence of the
genomes of cancer cells. Over the past quarter of a century much has been learnt about …
genomes of cancer cells. Over the past quarter of a century much has been learnt about …
Somatic mutation in cancer and normal cells
I Martincorena, PJ Campbell - Science, 2015 - science.org
Spontaneously occurring mutations accumulate in somatic cells throughout a person's
lifetime. The majority of these mutations do not have a noticeable effect, but some can alter …
lifetime. The majority of these mutations do not have a noticeable effect, but some can alter …
The myeloproliferative disorders
PJ Campbell, AR Green - New England Journal of Medicine, 2006 - Mass Medical Soc
The discovery of an identical mutation (V617F) of the JAK2 gene in patients with
polycythemia vera, essential thrombocythemia, and myelofibrosis—the principal …
polycythemia vera, essential thrombocythemia, and myelofibrosis—the principal …
Signatures of mutational processes in human cancer
All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …
processes generating these mutations is limited. The catalogue of somatic mutations from a …
[HTML][HTML] Genomic classification and prognosis in acute myeloid leukemia
Background Recent studies have provided a detailed census of genes that are mutated in
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic …
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic …
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …
the driver mutations conferring clonal advantage and the mutational processes generating …
COSMIC: the catalogue of somatic mutations in cancer
JG Tate, S Bamford, HC Jubb, Z Sondka… - Nucleic acids …, 2019 - academic.oup.com
Abstract COSMIC, the Catalogue Of Somatic Mutations In Cancer (https://cancer. sanger. ac.
uk) is the most detailed and comprehensive resource for exploring the effect of somatic …
uk) is the most detailed and comprehensive resource for exploring the effect of somatic …
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
EJ Baxter, LM Scott, PJ Campbell, C East… - The Lancet, 2005 - thelancet.com
Background Human myeloproliferative disorders form a range of clonal haematological
malignant diseases, the main members of which are polycythaemia vera, essential …
malignant diseases, the main members of which are polycythaemia vera, essential …
Clinical and biological implications of driver mutations in myelodysplastic syndromes
E Papaemmanuil, M Gerstung… - Blood, The Journal …, 2013 - ashpublications.org
Myelodysplastic syndromes (MDS) are a heterogeneous group of chronic hematological
malignancies characterized by dysplasia, ineffective hematopoiesis and a variable risk of …
malignancies characterized by dysplasia, ineffective hematopoiesis and a variable risk of …
[HTML][HTML] Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2
J Nangalia, CE Massie, EJ Baxter… - … England Journal of …, 2013 - Mass Medical Soc
Background Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many
myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative …
myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative …