All cancers arise as a result of changes that have occurred in the DNA sequence of the
genomes of cancer cells. Over the past quarter of a century much has been learnt about …

Spontaneously occurring mutations accumulate in somatic cells throughout a person's
lifetime. The majority of these mutations do not have a noticeable effect, but some can alter …

The discovery of an identical mutation (V617F) of the JAK2 gene in patients with
polycythemia vera, essential thrombocythemia, and myelofibrosis—the principal …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Background Recent studies have provided a detailed census of genes that are mutated in
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

Abstract COSMIC, the Catalogue Of Somatic Mutations In Cancer (https://cancer. sanger. ac.
uk) is the most detailed and comprehensive resource for exploring the effect of somatic …

Background Human myeloproliferative disorders form a range of clonal haematological
malignant diseases, the main members of which are polycythaemia vera, essential …

Myelodysplastic syndromes (MDS) are a heterogeneous group of chronic hematological
malignancies characterized by dysplasia, ineffective hematopoiesis and a variable risk of …

Background Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many
myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative …