Human milk‐derived fortifier versus bovine milk‐derived fortifier for prevention of mortality and morbidity in preterm neonates

MH Premkumar, M Pammi… - Cochrane Database of …, 2019 - cochranelibrary.com
Background Preterm infants who are fed breast milk in comparison to infant formula have
decreased morbidity such as necrotizing enterocolitis. Multi‐nutrient fortifiers used to …

[HTML][HTML] Fish oil–based lipid emulsions in the treatment of parenteral nutrition-associated liver disease: an ongoing positive experience

MH Premkumar, BA Carter, KM Hawthorne, K King… - Advances in …, 2014 - Elsevier
We previously reported the beneficial effect of fish oil-based lipid emulsions (FOLEs) as
monotherapy in the treatment of parenteral nutrition-associated liver disease (PNALD). In …

Requirement of argininosuccinate lyase for systemic nitric oxide production

A Erez, SCS Nagamani, OA Shchelochkov… - Nature medicine, 2011 - nature.com
Nitric oxide (NO) is crucial in diverse physiological and pathological processes. We show
that a hypomorphic mouse model of argininosuccinate lyase (encoded by Asl) deficiency …

High rates of resolution of cholestasis in parenteral nutrition-associated liver disease with fish oil-based lipid emulsion monotherapy

MH Premkumar, BA Carter, KM Hawthorne, K King… - The Journal of …, 2013 - Elsevier
OBJECTIVE: To determine factors leading to resolution of cholestasis in patients with
parenteral nutrition-associated liver disease treated with fish oil-based lipid emulsion …

[PDF][PDF] Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria

SCS Nagamani, PM Campeau… - The American Journal of …, 2012 - cell.com
Argininosuccinate lyase (ASL) is required for the synthesis and channeling of L-arginine to
nitric oxide synthase (NOS) for nitric oxide (NO) production. Congenital ASL deficiency …

[HTML][HTML] Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis

K MohanKumar, K Namachivayam… - Pediatric …, 2016 - nature.com
Background: Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature
infants. Based on our recent findings of increased Smad7 expression in surgically resected …

Nutritional management of short bowel syndrome

MH Premkumar, A Soraisham… - Clinics in …, 2022 - perinatology.theclinics.com
Intestinal failure (IF) is characterized by an inability to digest and absorb nutrients resulting
in dependence on parenteral nutrition (PN) due to loss of functional gut mass. 1, 2 IF in …

Fish oil emulsion reduces liver injury and liver transplantation in children with intestinal failure-associated liver disease: a multicenter integrated study

KM Gura, MH Premkumar, KL Calkins, M Puder - The Journal of pediatrics, 2021 - Elsevier
Objective To compare the aspartate aminotransferase to platelet ratio index, liver
transplantation, and mortality rates between children with intestinal failure-associated liver …

[PDF][PDF] Induction of nitric-oxide metabolism in enterocytes alleviates colitis and inflammation-associated colon cancer

N Stettner, C Rosen, B Bernshtein, S Gur-Cohen… - Cell Reports, 2018 - cell.com
Nitric oxide (NO) plays an established role in numerous physiological and pathological
processes, but the specific cellular sources of NO in disease pathogenesis remain unclear …

Prematurity reduces citrulline-arginine-nitric oxide production and precedes the onset of necrotizing enterocolitis in piglets

JL Robinson, VA Smith, B Stoll… - American Journal …, 2018 - journals.physiology.org
Necrotizing enterocolitis (NEC) is associated with low plasma arginine and vascular
dysfunction. It is not clear whether low intestinal citrulline production, the precursor for …