Reversible acetylation mediated by histone deacetylase (HDAC) influences a broad
repertoire of physiological processes, many of which are aberrantly controlled in tumour …

Post-translational modifications of histone and non-histone proteins by acetylation are
known to play a key role in tumourigenesis. Pharmacological manipulation of acetylation …

E2F transcription factors are implicated in diverse cellular functions. The founding member,
E2F‐1, is endowed with contradictory activities, being able to promote cell‐cycle …

Histone acetylation plays an important role in regulating the chromatin structure and is tightly
regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone …

In eukaryotes, genomic DNA is packaged with histone proteins into the cell nucleus as
chromatin, condensing the DNA> 10,000-fold. Chromatin is highly dynamic and exerts …

A series of 1∶ 1 complexes of hexafluorobenzene (HFB) with naphthalene, anthracene,
phenanthrene, pyrene and triphenylene were prepared and their X-ray crystal structures …

Molecular complexes of 1: 1 stoichiometry of octafluoronaphthalene (OFN) with the
polyaromatic hydrocarbons anthracene, phenanthrene, pyrene and triphenylene have been …

Histone deacetylase (HDAC) inhibitors are emergent cancer drugs. HR23B is a candidate
cancer biomarker identified in a genome-wide loss-of-function screen which influences …

The promising antitumor activity of 17-allylamino-17-demethoxygeldanamycin (17AAG)
results from inhibition of the molecular chaperone heat shock protein 90 (HSP90) and …

Aberrant acetylation has been strongly linked to tumorigenesis, and the modulation of
acetylation through targeting histone deacetylases (HDACs) is gathering increasing pace as …