User profiles for "author:K O’Rourke"

Karen O'Rourke

- Verified email at gene.com - Cited by 36827

Kevin Hjortshøj O'Rourke

- Verified email at nyu.edu - Cited by 18149

Keith O'Rourke

- Verified email at hc-sc.gc.ca - Cited by 12854

Meta-analysis in clinical research

KA L'ABBÉ, AS Detsky, K O'ROURKE - Annals of internal medicine, 1987 - acpjournals.org
Meta-analysis is the process of combining study results that can be used to draw conclusions
about therapeutic effectiveness or to plan new studies. We review important design and …

Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B: a meta-analysis

DKH Wong, AM Cheung, K O'Rourke… - Annals of internal …, 1993 - acpjournals.org
Purpose: To determine whether -interferon is effective in terminating viral replication and in
eradicating the carrier state in patients with chronic hepatitis B virus (HBV) infection. Data …

Globalization and inequality: historical trends

KH O'Rourke - 2001 - nber.org
This paper surveys trends in both international economic integration and inequality over the
past 150 years, as well as the links between them. In doing so, it distinguishes between (a) …

Cryopyrin activates the inflammasome in response to toxins and ATP

…, DS Weiss, K Newton, J McBride, K O'Rourke… - Nature, 2006 - nature.com
A crucial part of the innate immune response is the assembly of the inflammasome, a cytosolic
complex of proteins that activates caspase-1 to process the proinflammatory cytokines …

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

…, IB Stowe, BL Lee, K O'Rourke, K Anderson… - Nature, 2015 - nature.com
Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli,
Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse …

[BOOK][B] Globalization and history: the evolution of a nineteenth-century Atlantic economy

KH O'Rourke, JG Williamson - 2001 - books.google.com
Kevin O'Rourke and Jeffrey Williamson present a coherent picture of trade, migration, and
international capital flows in the Atlantic economy in the century prior to 1914—the first great …

Power and plenty: trade, war, and the world economy in the second millennium

R Findlay, KH O'rourke - Power and Plenty, 2009 - degruyter.com
… Ronald Findlay and Kevin O'Rourke examine the successive waves of globalization and" …
economic theory, Findlay and O'Rourke demonstrate the close interrelationships of trade and …

[HTML][HTML] FLICE, a novel FADD-homologous ICE/CED-3–like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex

M Muzio, AM Chinnaiyan, FC Kischkel, K O'Rourke… - Cell, 1996 - cell.com
To identify CAP3 and CAP4, components of the CD95 (Fas/APO-1) death-inducing signaling
complex, we utilized nano-electrospray tandem mass spectrometry, a recently developed …

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

AM Chinnaiyan, K O'Rourke, M Tewari, VM Dixit - Cell, 1995 - cell.com
Using the cytoplasmic domain of Fas in the yeast twohybrid system, we have identified a
novel interacting protein, FADD, which binds Fasand Fas-FD5, a mutant of Fas possessing …

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

IE Wertz, KM O'rourke, H Zhou, M Eby, L Aravind… - Nature, 2004 - nature.com
NF-κB transcription factors mediate the effects of pro-inflammatory cytokines such as tumour
necrosis factor-α and interleukin-1β 1 . Failure to downregulate NF-κB transcriptional activity …