Background Although therapeutic hypothermia reduces death or disability after neonatal
encephalopathy in high-income countries, its safety and efficacy in low-income and middle …

Background In neonatal encephalopathy, the clinical manifestations of injury can only be
reliably assessed several years after an intervention, complicating early prognostication and …

Although major cooling trials (and subsequent guidelines) excluded babies with mild
encephalopathy, anecdotal evidence suggests that cooling is often offered to these infants …

Objective To examine the effect of therapeutic hypothermia on MR biomarkers and
neurodevelopmental outcomes in babies with mild hypoxic-ischaemic encephalopathy …

Background Despite the increasing interest in fetal and neonatal heart rate variability (HRV)
analysis and its potential use as a tool for early disease stratification, no studies have …

Although therapeutic hypothermia (TH) is the standard of care for hypoxic ischaemic
encephalopathy in high-income countries, the safety and efficacy of this therapy in low …

Although therapeutic hypothermia (TH) improves outcomes after neonatal encephalopathy
(NE), the safety and efficacy of preemptive opioid sedation during cooling therapy is unclear …

Background: Variable responses to hypothermic neuroprotection are related to the clinical
heterogeneity of encephalopathic babies; hence better disease stratification may facilitate …

A rapid and early diagnostic test to identify the encephalopathic babies at risk of adverse
outcome may accelerate the development of neuroprotectants. We examined if a whole …

Although none of the major cooling trials mandated routine pre-emptive sedation, anecdotal
evidence suggests that opioids are widely used during neonatal cooling therapy. We …