User profiles for "author:Jaques Belik"

Jaques Belik

Professor of Pediatrics and Physiology, University of Toronto
Verified email at sickkids.ca
Cited by 4414

[HTML][HTML] Persistent pulmonary hypertension of the newborn: recent advances in pathophysiology and treatment

JEB Cabral, J Belik - Jornal de pediatria, 2013 - Elsevier
Objectives Although recognized for decades, little is known about the etiology,
physiopathology, and prevention of persistent pulmonary hypertension of the newborn …

Delayed childbearing and its impact on population rate changes in lower birth weight, multiple birth, and preterm delivery

SC Tough, C Newburn-Cook, DW Johnston… - …, 2002 - publications.aap.org
Objective. This study quantified the impact of delayed childbearing (maternal age≥ 35
years) on population rate changes in low birth weight (LBW;< 2500 g), preterm delivery (< 37 …

Fetal and neonatal effects of maternal drug treatment for depression

J Belik - Seminars in Perinatology, 2008 - Elsevier
Depression has a female sex predilection with 2 to 3% of the pregnant women population
presently requiring treatment with selective serotonin reuptake inhibitors (SSRI). Exposure to …

Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats

RP Jankov, C Kantores, J Pan… - American Journal of …, 2008 - journals.physiology.org
Xanthine oxidase (XO)-derived reactive oxygen species (ROS) formation contributes to
experimental chronic hypoxic pulmonary hypertension in adults, but its role in neonatal …

Isoprostanes in fetal and neonatal health and disease

J Belik, GE González-Luis, F Perez-Vizcaino… - Free Radical Biology …, 2010 - Elsevier
Isoprostanes are prostaglandin-like bioactive molecules generated via nonenzymatic
peroxidation of lipid membrane-derived arachidonic acid by free radicals and reactive …

Asymmetric dimethylarginine is increased in asthma

JA Scott, ML North, M Rafii, H Huang… - American journal of …, 2011 - atsjournals.org
Rationale: Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase
(NOS) inhibitor that competes with l-arginine for binding to NOS. It has been suggested that …

Early changes in lung gene expression due to high tidal volume

IB Copland, BP Kavanagh, D Engelberts… - American journal of …, 2003 - atsjournals.org
The purpose of this study was to use gene expression profiling to understand how adult rat
lung responds to high tidal volume (HV) ventilation in vivo. HV ventilation for 30 minutes did …

High tidal volume ventilation causes different inflammatory responses in newborn versus adult lung

IB Copland, F Martinez, BP Kavanagh… - American journal of …, 2004 - atsjournals.org
We investigated the effect of high VT ventilation on adult and newborn rats by examining
pulmonary injury and cytokine messenger RNA (mRNA). On the basis of compliance, edema …

Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat

E Fornaro, D Li, J Pan, J Belik - American journal of respiratory and …, 2007 - atsjournals.org
Rationale: Fluoxetine is a selective serotonin reuptake inhibitor antidepressant widely used
by pregnant women. Epidemiological data suggest that fluoxetine exposure prenatally …

Nasal high-frequency oscillation for lung carbon dioxide clearance in the newborn

A Mukerji, M Finelli, J Belik - Neonatology, 2013 - karger.com
Background: Noninvasive ventilation has been used increasingly in recent years to minimize
the duration of endotracheal mechanical ventilation in neonates due to its association with …