Major advances in therapeutic proteins, including antibody–drug conjugates (ADCs), have
created revolutionary drug delivery systems in cancer over the past decade. While these …

Cruzain is an essential cysteine protease of Trypanosoma cruzi and a therapeutic target for
Chagas' disease. Eight dogs were infected with T. cruzi; three were treated with an inhibitor …

Background: Sodium fluoride is the preferred agent to inhibit glycolysis. Its action is not
immediate, however, and complete inhibition is delayed for up to 4 hours. A more effective …

Nanotechnology provides many solutions to improve conventional drug delivery and has a
unique niche in the areas related to the specific targeting of the immune system, such as …

The rapid advancement in the development of therapeutic proteins, including monoclonal
antibodies (mAbs) and antibody-drug conjugates (ADCs), has created a novel mechanism to …

Antibodies that specifically bind polyethylene glycol (PEG), ie anti-PEG antibodies (APA),
are associated with reduced efficacy and increased risk of serious adverse events for …

Circulating antibodies that specifically bind polyethylene glycol (PEG), a polymer routinely
used in protein and nanoparticle therapeutics, have been associated with reduced efficacy …

Encorafenib is a kinase inhibitor indicated for the treatment of patients with BRAF mutant
melanoma and BRAF mutant metastatic colorectal cancer. To understand the effect of food …

Frequencies for the p-mode oscillations of Jupiter have been determined, and infrared
brightness temperature fluctuations are used to search for the modes. Measurements of the …

A review of 493 cases was undertaken to identify which patients undergoing hysterectomy
for benign disease had 1) received a preoperative intravenous pyelogram (IVP), 2) an …