Nitric oxide‐mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases
JP Bolaños, A Almeida, V Stewart… - Journal of …, 1997 - Wiley Online Library
Within the CNS and under normal conditions, nitric oxide (• NO) appears to be an important
physiological signalling molecule. Its ability to increase cyclic GMP concentration suggests …
physiological signalling molecule. Its ability to increase cyclic GMP concentration suggests …
[HTML][HTML] Nitric oxide, mitochondria and neurological disease
SJR Heales, JP Bolaños, VC Stewart… - … et Biophysica Acta (BBA …, 1999 - Elsevier
Damage to the mitochondrial electron transport chain has been suggested to be an
important factor in the pathogenesis of a range of neurological disorders, such as …
important factor in the pathogenesis of a range of neurological disorders, such as …
[HTML][HTML] Oxidative stress and mitochondrial dysfunction in neurodegeneration; cardiolipin a critical target?
S Pope, JM Land, SJR Heales - Biochimica et Biophysica Acta (BBA) …, 2008 - Elsevier
Oxidative stress and subsequent impairment of mitochondrial function is implicated in the
neurodegenerative process and hence in diseases such as Parkinson's and Alzheimer's …
neurodegenerative process and hence in diseases such as Parkinson's and Alzheimer's …
β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities
CS Casley, L Canevari, JM Land… - Journal of …, 2002 - Wiley Online Library
Disrupted energy metabolism, in particular reduced activity of cytochrome oxidase (EC 1.9.
3.1), α‐ketoglutarate dehydrogenase (EC 1.2. 4.2) and pyruvate dehydrogenase (EC 1.2 …
3.1), α‐ketoglutarate dehydrogenase (EC 1.2. 4.2) and pyruvate dehydrogenase (EC 1.2 …
Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture
JP Bolaños, SJR Heales, JM Land… - Journal of …, 1995 - Wiley Online Library
The effect of the neurotoxic nitric oxide derivative, the peroxynitrite anion (ONOO−), on the
activity of the mitochondrial respiratory chain complexes in cultured neurones and astrocytes …
activity of the mitochondrial respiratory chain complexes in cultured neurones and astrocytes …
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
KM Holmström, L Baird, Y Zhang, I Hargreaves… - Biology …, 2013 - journals.biologists.com
Transcription factor Nrf2 and its repressor Keap1 regulate a network of cytoprotective genes
involving more than 1% of the genome, their best known targets being drug-metabolizing …
involving more than 1% of the genome, their best known targets being drug-metabolizing …
Nitric oxide‐mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes
JP Bolanos, S Peuchen, SJR Heales… - Journal of …, 1994 - Wiley Online Library
The Ca2+‐independent form of nitric oxide synthase was induced in rat neonatal astrocytes
in primary culture by incubation with lipopolysaccharide (1 µg/ml) plus interferon‐γ (100 …
in primary culture by incubation with lipopolysaccharide (1 µg/ml) plus interferon‐γ (100 …
Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione
JP Bolaños, SJR Heales, S Peuchen, JE Barker… - Free Radical Biology …, 1996 - Elsevier
In this study we have investigated the mechanisms leading to mitochondrial damage in
cultured neurons following sustained exposure to nitric oxide. Thus, the effects upon …
cultured neurons following sustained exposure to nitric oxide. Thus, the effects upon …
β-Amyloid fragment 25–35 causes mitochondrial dysfunction in primary cortical neurons
CS Casley, JM Land, MA Sharpe, JB Clark… - Neurobiology of …, 2002 - Elsevier
β-Amyloid deposition and compromised energy metabolism both occur in vulnerable brain
regions in Alzheimer's disease. It is not known whether β-amyloid is the cause of impairment …
regions in Alzheimer's disease. It is not known whether β-amyloid is the cause of impairment …
Treatable childhood neuronopathy caused by mutations in riboflavin transporter RFVT2
AR Foley, MP Menezes, A Pandraud, MA Gonzalez… - Brain, 2014 - academic.oup.com
Childhood onset motor neuron diseases or neuronopathies are a clinically heterogeneous
group of disorders. A particularly severe subgroup first described in 1894, and subsequently …
group of disorders. A particularly severe subgroup first described in 1894, and subsequently …