The psychencode project
Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …
involved in global gene regulation and chromatin modification, as well as many common …
A nomenclature consensus for nervous system organoids and assembloids
Self-organizing three-dimensional cellular models derived from human pluripotent stem
cells or primary tissue have great potential to provide insights into how the human nervous …
cells or primary tissue have great potential to provide insights into how the human nervous …
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network
BACKGROUND Elucidating the genetic architecture of neuropsychiatric disorders remains a
major scientific and medical challenge. Emerging genomic technologies now permit the …
major scientific and medical challenge. Emerging genomic technologies now permit the …
[PDF][PDF] FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders
Autism spectrum disorder (ASD) is a disorder of brain development. Most cases lack a clear
etiology or genetic basis, and the difficulty of re-enacting human brain development has …
etiology or genetic basis, and the difficulty of re-enacting human brain development has …
Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome
PSA Kalanithi, W Zheng, Y Kataoka… - Proceedings of the …, 2005 - National Acad Sciences
Tourette syndrome (TS) is a childhood neuropsychiatric disorder characterized by motor and
vocal tics. Imaging studies found alterations in caudate (Cd) and putamen volumes. To …
vocal tics. Imaging studies found alterations in caudate (Cd) and putamen volumes. To …
Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex
R Raballo, J Rhee, R Lyn-Cook… - Journal of …, 2000 - Soc Neuroscience
Little is known about regionally specific signals that control the number of neuronal
progenitor cells in vivo. We have previously shown that the germline mutation of the basic …
progenitor cells in vivo. We have previously shown that the germline mutation of the basic …
Modeling human cortical development in vitro using induced pluripotent stem cells
J Mariani, MV Simonini, D Palejev… - Proceedings of the …, 2012 - National Acad Sciences
Human induced pluripotent stem cells (hiPSCs) are emerging as a tool for understanding
human brain development at cellular, molecular, and genomic levels. Here we show that …
human brain development at cellular, molecular, and genomic levels. Here we show that …
Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome
Y Kataoka, PSA Kalanithi, H Grantz… - Journal of …, 2010 - Wiley Online Library
Corticobasal ganglia neuronal ensembles bring automatic motor skills into voluntary control
and integrate them into ongoing motor behavior. A 5% decrease in caudate (Cd) nucleus …
and integrate them into ongoing motor behavior. A 5% decrease in caudate (Cd) nucleus …
Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells
Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has been
suspected of causing de novo copy number variation,,,. To explore this issue, here we …
suspected of causing de novo copy number variation,,,. To explore this issue, here we …
Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis
FM Vaccarino, ML Schwartz, R Raballo, J Nilsen… - Nature …, 1999 - nature.com
We show that fibroblast growth factor 2 (FGF2) and FGF receptors are transiently expressed
by cells of the pseudostratified ventricular epithelium (PVE) during early neurogenesis. A …
by cells of the pseudostratified ventricular epithelium (PVE) during early neurogenesis. A …