The psychencode project

S Akbarian, C Liu, JA Knowles, FM Vaccarino… - Nature …, 2015 - nature.com
Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

A nomenclature consensus for nervous system organoids and assembloids

SP Pașca, P Arlotta, HS Bateup, JG Camp, S Cappello… - Nature, 2022 - nature.com
Self-organizing three-dimensional cellular models derived from human pluripotent stem
cells or primary tissue have great potential to provide insights into how the human nervous …

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

MJ McConnell, JV Moran, A Abyzov, S Akbarian, T Bae… - Science, 2017 - science.org
BACKGROUND Elucidating the genetic architecture of neuropsychiatric disorders remains a
major scientific and medical challenge. Emerging genomic technologies now permit the …

[PDF][PDF] FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders

J Mariani, G Coppola, P Zhang, A Abyzov, L Provini… - Cell, 2015 - cell.com
Autism spectrum disorder (ASD) is a disorder of brain development. Most cases lack a clear
etiology or genetic basis, and the difficulty of re-enacting human brain development has …

Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome

PSA Kalanithi, W Zheng, Y Kataoka… - Proceedings of the …, 2005 - National Acad Sciences
Tourette syndrome (TS) is a childhood neuropsychiatric disorder characterized by motor and
vocal tics. Imaging studies found alterations in caudate (Cd) and putamen volumes. To …

Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex

R Raballo, J Rhee, R Lyn-Cook… - Journal of …, 2000 - Soc Neuroscience
Little is known about regionally specific signals that control the number of neuronal
progenitor cells in vivo. We have previously shown that the germline mutation of the basic …

Modeling human cortical development in vitro using induced pluripotent stem cells

J Mariani, MV Simonini, D Palejev… - Proceedings of the …, 2012 - National Acad Sciences
Human induced pluripotent stem cells (hiPSCs) are emerging as a tool for understanding
human brain development at cellular, molecular, and genomic levels. Here we show that …

Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome

Y Kataoka, PSA Kalanithi, H Grantz… - Journal of …, 2010 - Wiley Online Library
Corticobasal ganglia neuronal ensembles bring automatic motor skills into voluntary control
and integrate them into ongoing motor behavior. A 5% decrease in caudate (Cd) nucleus …

Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells

A Abyzov, J Mariani, D Palejev, Y Zhang, MS Haney… - Nature, 2012 - nature.com
Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has been
suspected of causing de novo copy number variation,,,. To explore this issue, here we …

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis

FM Vaccarino, ML Schwartz, R Raballo, J Nilsen… - Nature …, 1999 - nature.com
We show that fibroblast growth factor 2 (FGF2) and FGF receptors are transiently expressed
by cells of the pseudostratified ventricular epithelium (PVE) during early neurogenesis. A …