BACKGROUND: Serum specific IgE or skin prick tests are less useful at levels below
accepted decision points. OBJECTIVES: We sought to develop and validate a model to …

Inflammatory bowel diseases (IBD), categorized as ulcerative colitis (UC), Crohn's disease
(CD), or IBD-undetermined (IBDU), are increasing in incidence. IBD is understood to result …

The National Institute for Health and Care Excellence (NICE) published a clinical guideline
in 2013 entitled 'Ulcerative colitis: Management in adults, children and young people (NICE …

Crohn's disease (CD) is a lifelong inflammatory bowel disease with a rapidly rising
incidence in the pediatric population. A common complication of CD is the development of …

Dysregulated redox signaling and oxidative injury are associated with inflammatory
processes and fibrosis. H 2 O 2 generation by NOX4 has been suggested as a key driver in …

Background: Outcomes in pediatric ulcerative colitis (UC) are heterogeneous and predictors
of disease course eagerly sought. Mucosal atrophy (MA) is characterized by histological …

Background Basic life support guidelines recommend placing spontaneously breathing
children and adults on their side. Though the majority of preterm newborns breathe …

Congenital diarrheas and enteropathies (CODEs) constitute a heterogeneous group of
individually rare disorders manifesting with infantile-onset chronic diarrhea. Genomic …

In recent decades our understanding of the gut microbiota has evolved from one of a host-
pathogen relationship resulting in disease (eg. gastroenteritis, H pylori ulcers), to one …

Alagille syndrome (ALGS) is a rare genetic disorder of the Jagged1-Notch2 inter-cellular
signalling system, of autosomal dominant inheritance with variable penetrance as haplo …