Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion

CA Llewelyn, PE Hewitt, RSG Knight, K Amar… - The Lancet, 2004 - thelancet.com
Summary Background Variant Creutzfeldt-Jakob disease (vCJD) is a novel human prion
disease caused by infection with the agent of bovine spongiform encephalopathy (BSE) …

[HTML][HTML] A no-prophylaxis platelet-transfusion strategy for hematologic cancers

SJ Stanworth, LJ Estcourt, G Powter… - … England Journal of …, 2013 - Mass Medical Soc
Background The effectiveness of platelet transfusions to prevent bleeding in patients with
hematologic cancers remains unclear. This trial assessed whether a policy of not giving …

[HTML][HTML] Randomized trial of platelet-transfusion thresholds in neonates

A Curley, SJ Stanworth, K Willoughby… - … England Journal of …, 2019 - Mass Medical Soc
Background Platelet transfusions are commonly used to prevent bleeding in preterm infants
with thrombocytopenia. Data are lacking to provide guidance regarding thresholds for …

Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial

V Jairath, BC Kahan, A Gray, CJ Doré, A Mora… - The Lancet, 2015 - thelancet.com
Background Transfusion thresholds for acute upper gastrointestinal bleeding are
controversial. So far, only three small, underpowered studies and one single-centre trial …

The Transfusion Alternatives Preoperatively in Sickle Cell Disease (TAPS) study: a randomised, controlled, multicentre clinical trial

J Howard, M Malfroy, C Llewelyn, L Choo, R Hodge… - The Lancet, 2013 - thelancet.com
Background No consensus exists on whether preoperative blood transfusions are beneficial
in patients with sickle-cell disease. We assessed whether perioperative complication rates …

Do all patients with hematologic malignancies and severe thrombocytopenia need prophylactic platelet transfusions?: Background, rationale, and design of a clinical …

SJ Stanworth, C Dyer, L Choo, L Bakrania… - Transfusion medicine …, 2010 - Elsevier
Although considerable advances have been made in many aspects of platelet transfusion
therapy in the last 30 years, some areas continue to provoke debate, including the use of …

Impact of prophylactic platelet transfusions on bleeding events in patients with hematologic malignancies: a subgroup analysis of a randomized trial (CME)

SJ Stanworth, LJ Estcourt, CA Llewelyn… - …, 2014 - Wiley Online Library
Background A recent randomized trial compared a policy of no prophylaxis with a policy of
prophylactic platelet (PLT) transfusions at counts of fewer than 10× 109/L in patients with …

The EASTR Study: indications for transfusion and estimates of transfusion recipient numbers in hospitals supplied by the National Blood Service

AW Wells, CA Llewelyn, A Casbard… - Transfusion …, 2009 - Wiley Online Library
This study provides data on National Blood Service (NBS) red blood cell (RBC, n= 9142),
platelet (PLT, n= 4232) and fresh frozen plasma (FFP, n= 3584) recipients independently …

Two-year outcomes following a randomised platelet transfusion trial in preterm infants

CM Moore, A D'Amore, S Fustolo-Gunnink… - Archives of Disease in …, 2023 - fn.bmj.com
Objective Assess mortality and neurodevelopmental outcomes at 2 years of corrected age in
children who participated in the PlaNeT-2/MATISSE (Platelets for Neonatal Transfusion …

The effect of universal leukoreduction on postoperative infections and length of hospital stay in elective orthopedic and cardiac surgery

CA Llewelyn, RS Taylor, AAM Todd, W Stevens… - …, 2004 - Wiley Online Library
BACKGROUND: A before and after study was under‐taken to investigate the effect of
universal leukoreduction (ULR) in the UK on postoperative length of hospital stay (LOS) and …