User profiles for "author:C Scott"

CP Scott

CanmetMATERIALS, Hamilton Ontario
Verified email at nrcan.gc.ca
Cited by 4711

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

DD Bowtell, S Böhm, AA Ahmed, PJ Aspuria… - Nature reviews …, 2015 - nature.com
High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article …

High manganese austenitic twinning induced plasticity steels: A review of the microstructure properties relationships

O Bouaziz, S Allain, CP Scott, P Cugy… - Current opinion in solid …, 2011 - Elsevier
A significant increase in the research activity dedicated to high manganese TWIP steels has
occurred during the past five years, motivated by the breakthrough combination of strength …

Target-enrichment strategies for next-generation sequencing

L Mamanova, AJ Coffey, CE Scott, I Kozarewa… - Nature …, 2010 - nature.com
We have not yet reached a point at which routine sequencing of large numbers of whole
eukaryotic genomes is feasible, and so it is often necessary to select genomic regions of …

[HTML][HTML] The zebrafish reference genome sequence and its relationship to the human genome

…, S McLaren, I Sealy, M Caccamo, C Churcher, C Scott… - Nature, 2013 - nature.com
Zebrafish have become a popular organism for the study of vertebrate gene function,. The
virtually transparent embryos of this species, and the ability to accelerate genetic studies by …

Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled …

RL Coleman, AM Oza, D Lorusso, C Aghajanian… - The Lancet, 2017 - thelancet.com
Background Rucaparib, a poly (ADP-ribose) polymerase inhibitor, has anticancer activity in
recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome …

Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 …

DW Andrews, CB Scott, PW Sperduto, AE Flanders… - The Lancet, 2004 - thelancet.com
Background Brain metastases occur in up to 40% of all patients with systemic cancer. We
aimed to assess whether stereotactic radiosurgery provided any therapeutic benefit in a …

Burden of valvular heart diseases: a population-based study

VT Nkomo, JM Gardin, TN Skelton, JS Gottdiener… - The lancet, 2006 - thelancet.com
Background Valvular heart diseases are not usually regarded as a major public-health
problem. Our aim was to assess their prevalence and effect on overall survival in the general …

Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind …

…, AP Aparicio, LV Boixader, C Scott… - The lancet …, 2017 - thelancet.com
Background Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has previously
shown efficacy in a phase 2 study when given in capsule formulation to all-comer patients …

[HTML][HTML] Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer

…, I Vergote, G Rustin, C Scott… - … England Journal of …, 2012 - Mass Medical Soc
Background Olaparib (AZD2281) is an oral poly (adenosine diphosphate [ADP]–ribose)
polymerase inhibitor that has shown antitumor activity in patients with high-grade serous …

[HTML][HTML] Analyses of pig genomes provide insight into porcine demography and evolution

…, JG Schraiber, J Schwartz, L Scobie, C Scott… - Nature, 2012 - nature.com
For 10,000 years pigs and humans have shared a close and complex relationship. From
domestication to modern breeding practices, humans have shaped the genomes of …