User profiles for "author:B Engels"

Bernd Engels

retired Professor, University of Würzburg
Verified email at uni-wuerzburg.de
Cited by 11203

Principles and effects of microRNA-mediated post-transcriptional gene regulation

BM Engels, G Hutvagner - Oncogene, 2006 - nature.com
MicroRNAs (miRNAs) are abundant regulatory RNAs involved in the regulation of many key
biological processes. Recent advances in understanding the mechanism of RNA …

Nitrogen fixation and reduction at boron

…, RD Dewhurst, E Welz, I Krummenacher, B Engels… - Science, 2018 - science.org
Currently, the only compounds known to support fixation and functionalization of dinitrogen
(N2) under nonmatrix conditions are based on metals. Here we present the observation of …

[PDF][PDF] Engineered CAR T cells targeting the cancer-associated Tn-glycoform of the membrane mucin MUC1 control adenocarcinoma

…, AC Boesteanu, C Steentoft, U Mandel, B Engels… - Immunity, 2016 - cell.com
Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate
robust responses against lineage restricted, non-essential targets in hematologic cancers …

Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma

…, JA Fraietta, CC Kloss, AD Posey Jr, B Engels… - Science translational …, 2015 - science.org
Chimeric antigen receptors (CARs) are synthetic molecules designed to redirect T cells to
specific antigens. CAR-modified T cells can mediate long-term durable remissions in B cell …

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

B Engels, P Dahm, S Jennewein - Metabolic engineering, 2008 - Elsevier
Metabolic engineering in microbes could be used to produce large amounts of valuable
metabolites that are difficult to extract from their natural sources and too expensive or …

Exciton trapping in π-conjugated materials: A quantum-chemistry-based protocol applied to perylene bisimide dye aggregates

…, J Pfister, F Würthner, B Engels - Journal of the …, 2008 - ACS Publications
Access to excited-state structures and dynamics of π-chromophor aggregates is needed to
understand their fluorescence behavior and the properties of related materials. A quantum …

Targeting stroma to treat cancers

B Engels, DA Rowley, H Schreiber - Seminars in cancer biology, 2012 - Elsevier
All cancers depend on stroma for support of growth. Leukemias, solid tumors, cancer cells
causing effusions, metastases as well as micro-disseminated cancer cells release factors …

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

N Singh, NV Frey, B Engels, DM Barrett, O Shestova… - Nature medicine, 2021 - nature.com
While CD19-directed chimeric antigen receptor (CAR) T cells can induce remission in
patients with B cell acute lymphoblastic leukemia (ALL), a large subset relapse with CD19 …

Comparison of different rate constant expressions for the prediction of charge and energy transport in oligoacenes

…, M Tafipolski, C Deibel, B Engels - Wiley Interdisciplinary …, 2016 - Wiley Online Library
Charge and exciton transport in organic semiconductors is crucial for a variety of
optoelectronic applications. The prediction of the material‐dependent exciton diffusion …

[HTML][HTML] Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses

…, M Ruella, J Scholler, B Keith, RM Young, B Engels… - JCI insight, 2018 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDA) is characterized by its highly immunosuppressive
tumor microenvironment (TME) that limits T cell infiltration and induces T cell hypofunction …