The rise and fall of mutator bacteria
Bacteria with elevated mutation rates are frequently found among natural isolates. This is
probably because of their ability to generate genetic variability, the substrate for natural …
probably because of their ability to generate genetic variability, the substrate for natural …
Costs and benefits of high mutation rates: adaptive evolution of bacteria in the mouse gut
We have shown that bacterial mutation rates change during the experimental colonization of
the mouse gut. A high mutation rate was initially beneficial because it allowed faster …
the mouse gut. A high mutation rate was initially beneficial because it allowed faster …
[HTML][HTML] Improved survival using specialized multidisciplinary board in sarcoma patients
JY Blay, P Soibinet, N Penel, E Bompas, F Duffaud… - Annals of …, 2017 - Elsevier
Background Sarcomas are rare but aggressive diseases. Specialized multidisciplinary
management is not implemented for all patients in most countries. We investigated the …
management is not implemented for all patients in most countries. We investigated the …
[HTML][HTML] Role of perinatal inflammation in neonatal arterial ischemic stroke
A Giraud, C Guiraut, M Chevin, S Chabrier… - Frontiers in …, 2017 - frontiersin.org
Based on the review of the literature, perinatal inflammation often induced by infection is the
only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS) …
only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS) …
[HTML][HTML] Surgery in reference centers improves survival of sarcoma patients: a nationwide study
JY Blay, C Honore, E Stoeckle, P Meeus, M Jafari… - Annals of …, 2019 - Elsevier
Background NETSARC (netsarc. org) is a network of 26 sarcoma reference centers with
specialized multidisciplinary tumor boards (MDTB) aiming to improve the outcome of …
specialized multidisciplinary tumor boards (MDTB) aiming to improve the outcome of …
Identification and characterization of VEGF-A–responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans
S Massena, G Christoffersson… - Blood, The Journal …, 2015 - ashpublications.org
Vascular endothelial growth factor A (VEGF-A) is upregulated during hypoxia and is the
major regulator of angiogenesis. VEGF-A expression has also been found to recruit myeloid …
major regulator of angiogenesis. VEGF-A expression has also been found to recruit myeloid …
High Frequency of Mutator Strains among Human Uropathogenic Escherichia coli Isolates
By using a panel of 603 commensal and pathogenic Escherichia coli and Shigella isolates,
we showed that mutation rates of strains vary considerably among different ecotypes …
we showed that mutation rates of strains vary considerably among different ecotypes …
[HTML][HTML] Patterns of care and outcomes of patients with METAstatic soft tissue SARComa in a real-life setting: the METASARC observational study
M Savina, A Le Cesne, JY Blay, I Ray-Coquard, O Mir… - BMC medicine, 2017 - Springer
Background Well-designed observational studies of individuals with rare tumors are needed
to improve patient care, clinical investigations, and the education of healthcare …
to improve patient care, clinical investigations, and the education of healthcare …
[HTML][HTML] Surgical versus non-surgical approach in primary desmoid-type fibromatosis patients: a nationwide prospective cohort from the French Sarcoma Group
N Penel, A Le Cesne, S Bonvalot, A Giraud… - European journal of …, 2017 - Elsevier
Purpose The outcome of desmoid-type fibromatosis (DTF) is unpredictable. Currently, a wait-
and-see approach tends to replace large en bloc resection as the first therapeutic approach …
and-see approach tends to replace large en bloc resection as the first therapeutic approach …
[HTML][HTML] In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain
The capacity of non-pathogenic enteric bacteria to induce a pro-inflammatory response is
under debate in terms of its effect on the symbiosis between the mammalian host and its …
under debate in terms of its effect on the symbiosis between the mammalian host and its …