Chronic kidney disease of unknown aetiology in Sri Lanka and the exposure to environmental chemicals: a review of literature
M Kulathunga, MA Ayanka Wijayawardena… - … geochemistry and health, 2019 - Springer
Chronic kidney disease of unknown aetiology (CKDu) has emerged as a serious health
issue in Sri Lanka. The disease has been recorded in the North Central Province of the …
issue in Sri Lanka. The disease has been recorded in the North Central Province of the …
[HTML][HTML] Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation
H Xu, K Van der Jeught, Z Zhou… - The Journal of …, 2021 - Am Soc Clin Investig
One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity,
which arises due to lack of immunogenic tumor antigens as well as dysregulation of the …
which arises due to lack of immunogenic tumor antigens as well as dysregulation of the …
[HTML][HTML] Gene content evolution in the arthropods
Background Arthropods comprise the largest and most diverse phylum on Earth and play
vital roles in nearly every ecosystem. Their diversity stems in part from variations on a …
vital roles in nearly every ecosystem. Their diversity stems in part from variations on a …
[HTML][HTML] RNA-Seq and molecular docking reveal multi-level pesticide resistance in the bed bug
Abstract Background Bed bugs (Cimex lectularius) are hematophagous nocturnal parasites
of humans that have attained high impact status due to their worldwide resurgence. The …
of humans that have attained high impact status due to their worldwide resurgence. The …
[HTML][HTML] Bassoon contributes to tau-seed propagation and neurotoxicity
Tau aggregation is a defining histopathological feature of Alzheimer's disease and other
tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear …
tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear …
Analysis of Arabidopsis genome-wide variations before and after meiosis and meiotic recombination by resequencing Landsberg erecta and all four products of a …
Meiotic recombination, including crossovers (COs) and gene conversions (GCs), impacts
natural variation and is an important evolutionary force. COs increase genetic diversity by …
natural variation and is an important evolutionary force. COs increase genetic diversity by …
COVID-19 deaths in people with intellectual disability in the UK and Ireland: descriptive study
…, R Alexander, K Purandare, A Wijeratne… - BJPsych …, 2020 - cambridge.org
BackgroundRapid spread of coronavirus disease 2019 (COVID-19) has affected people with
intellectual disability disproportionately. Existing data does not provide enough information …
intellectual disability disproportionately. Existing data does not provide enough information …
[HTML][HTML] Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic β cell
Alterations in endoplasmic reticulum (ER) calcium (Ca 2+) levels diminish insulin secretion
and reduce β-cell survival in both major forms of diabetes. The mechanisms responsible for …
and reduce β-cell survival in both major forms of diabetes. The mechanisms responsible for …
Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity
Preclinical studies of primary cancer cells are typically done after tumors are removed from
patients or animals at ambient atmospheric oxygen (O2,~ 21%). However, O2 …
patients or animals at ambient atmospheric oxygen (O2,~ 21%). However, O2 …
[HTML][HTML] Prevalence and severity of pruritus and quality of life in patients with cutaneous T-cell lymphoma
A Wright, A Wijeratne, T Hung, W Gao… - Journal of pain and …, 2013 - Elsevier
CONTEXT: Cutaneous T-cell lymphoma (CTCL), although rare, is associated with a
significant symptom burden. Pruritus appears to be one of the most prominent and disturbing …
significant symptom burden. Pruritus appears to be one of the most prominent and disturbing …