User profiles for "author:A SHARPLES"
Adam P SharplesProfessor of Epigenetics and Molecular Physiology Verified email at nih.no Cited by 3104 |
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training
B Egan, AP Sharples - Physiological Reviews, 2023 - journals.physiology.org
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …
exercise training are a potent stimulus for physiological adaptation in many organs …
Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake
Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and
function. Given the worldwide aging demographics, this is a major contributor to morbidity …
function. Given the worldwide aging demographics, this is a major contributor to morbidity …
Does skeletal muscle have an 'epi'‐memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise
AP Sharples, CE Stewart, RA Seaborne - Aging cell, 2016 - Wiley Online Library
Skeletal muscle mass, quality and adaptability are fundamental in promoting muscle
performance, maintaining metabolic function and supporting longevity and healthspan …
performance, maintaining metabolic function and supporting longevity and healthspan …
[HTML][HTML] Human skeletal muscle possesses an epigenetic memory of hypertrophy
It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters
with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 …
with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 …
[HTML][HTML] A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy
DJ Owens, AP Sharples, I Polydorou… - American Journal …, 2015 - journals.physiology.org
Skeletal muscle is a direct target for vitamin D. Observational studies suggest that low 25
[OH] D correlates with functional recovery of skeletal muscle following eccentric contractions …
[OH] D correlates with functional recovery of skeletal muscle following eccentric contractions …
Fuel for the work required: a practical approach to amalgamating train‐low paradigms for endurance athletes
SG Impey, KM Hammond, SO Shepherd… - Physiological …, 2016 - Wiley Online Library
Using an amalgamation of previously studied “train‐low” paradigms, we tested the effects of
reduced carbohydrate (CHO) but high leucine availability on cell‐signaling responses …
reduced carbohydrate (CHO) but high leucine availability on cell‐signaling responses …
Systematic review and meta-analysis of randomised controlled trials comparing long-term outcomes of Roux-En-Y gastric bypass and sleeve gastrectomy
AJ Sharples, K Mahawar - Obesity surgery, 2020 - Springer
Introduction Sleeve gastrectomy (SG) has overtaken Roux-En-Y gastric bypass (RYGB) as
the most common bariatric procedure worldwide. However, there is little long-term data …
the most common bariatric procedure worldwide. However, there is little long-term data …
[HTML][HTML] Comparative transcriptome and methylome analysis in human skeletal muscle anabolism, hypertrophy and epigenetic memory
Transcriptome wide changes in human skeletal muscle after acute (anabolic) and chronic
resistance exercise (RE) induced hypertrophy have been extensively determined in the …
resistance exercise (RE) induced hypertrophy have been extensively determined in the …
An approach to consensus building using the Delphi technique: developing a learning resource in mental health
SB Sharkey, AY Sharples - Nurse education today, 2001 - Elsevier
Health service research is best served through the collaboration of researchers and
practitioners. This study utilizes a multi-method approach in developing a learning resource …
practitioners. This study utilizes a multi-method approach in developing a learning resource …
[HTML][HTML] DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity
Skeletal muscle tissue demonstrates global hypermethylation with age. However,
methylome changes across the time-course of differentiation in aged human muscle derived …
methylome changes across the time-course of differentiation in aged human muscle derived …