User profiles for "author:A SHARPLES"

Adam P Sharples

Professor of Epigenetics and Molecular Physiology
Verified email at nih.no
Cited by 3104

Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training

B Egan, AP Sharples - Physiological Reviews, 2023 - journals.physiology.org
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake

AP Sharples, DC Hughes, CS Deane, A Saini… - Aging cell, 2015 - Wiley Online Library
Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and
function. Given the worldwide aging demographics, this is a major contributor to morbidity …

Does skeletal muscle have an 'epi'‐memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise

AP Sharples, CE Stewart, RA Seaborne - Aging cell, 2016 - Wiley Online Library
Skeletal muscle mass, quality and adaptability are fundamental in promoting muscle
performance, maintaining metabolic function and supporting longevity and healthspan …

[HTML][HTML] Human skeletal muscle possesses an epigenetic memory of hypertrophy

RA Seaborne, J Strauss, M Cocks, S Shepherd… - Scientific reports, 2018 - nature.com
It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters
with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 …

[HTML][HTML] A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy

DJ Owens, AP Sharples, I Polydorou… - American Journal …, 2015 - journals.physiology.org
Skeletal muscle is a direct target for vitamin D. Observational studies suggest that low 25
[OH] D correlates with functional recovery of skeletal muscle following eccentric contractions …

Fuel for the work required: a practical approach to amalgamating train‐low paradigms for endurance athletes

SG Impey, KM Hammond, SO Shepherd… - Physiological …, 2016 - Wiley Online Library
Using an amalgamation of previously studied “train‐low” paradigms, we tested the effects of
reduced carbohydrate (CHO) but high leucine availability on cell‐signaling responses …

Systematic review and meta-analysis of randomised controlled trials comparing long-term outcomes of Roux-En-Y gastric bypass and sleeve gastrectomy

AJ Sharples, K Mahawar - Obesity surgery, 2020 - Springer
Introduction Sleeve gastrectomy (SG) has overtaken Roux-En-Y gastric bypass (RYGB) as
the most common bariatric procedure worldwide. However, there is little long-term data …

[HTML][HTML] Comparative transcriptome and methylome analysis in human skeletal muscle anabolism, hypertrophy and epigenetic memory

DC Turner, RA Seaborne, AP Sharples - Scientific reports, 2019 - nature.com
Transcriptome wide changes in human skeletal muscle after acute (anabolic) and chronic
resistance exercise (RE) induced hypertrophy have been extensively determined in the …

An approach to consensus building using the Delphi technique: developing a learning resource in mental health

SB Sharkey, AY Sharples - Nurse education today, 2001 - Elsevier
Health service research is best served through the collaboration of researchers and
practitioners. This study utilizes a multi-method approach in developing a learning resource …

[HTML][HTML] DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity

DC Turner, PP Gorski, MF Maasar, RA Seaborne… - Scientific Reports, 2020 - nature.com
Skeletal muscle tissue demonstrates global hypermethylation with age. However,
methylome changes across the time-course of differentiation in aged human muscle derived …