The role of aspirin, heparin, and other interventions in the prevention and treatment of fetal growth restriction

KM Groom, AL David - American journal of obstetrics and gynecology, 2018 - Elsevier
Fetal growth restriction and related placental pathologies such as preeclampsia, stillbirth,
and placental abruption are believed to arise in early pregnancy when inadequate …

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

JL Morrison, KJ Botting, JRT Darby… - The Journal of …, 2018 - Wiley Online Library
Abstract Over 30 years ago Professor David Barker first proposed the theory that events in
early life could explain an individual's risk of non‐communicable disease in later life: the …

Maternal complications following open and fetoscopic fetal surgery: a systematic review and meta‐analysis

A Sacco, L Van der Veeken, E Bagshaw… - Prenatal …, 2019 - Wiley Online Library
Objective To establish maternal complication rates for fetoscopic or open fetal surgery.
Methods We conducted a systematic literature review for studies of fetoscopic or open fetal …

Interactive medical image segmentation using deep learning with image-specific fine tuning

G Wang, W Li, MA Zuluaga, R Pratt… - IEEE transactions on …, 2018 - ieeexplore.ieee.org
Convolutional neural networks (CNNs) have achieved state-of-the-art performance for
automatic medical image segmentation. However, they have not demonstrated sufficiently …

DeepIGeoS: a deep interactive geodesic framework for medical image segmentation

G Wang, MA Zuluaga, W Li, R Pratt… - IEEE transactions on …, 2018 - ieeexplore.ieee.org
Accurate medical image segmentation is essential for diagnosis, surgical planning and
many other applications. Convolutional Neural Networks (CNNs) have become the state-of …

[HTML][HTML] An automated framework for localization, segmentation and super-resolution reconstruction of fetal brain MRI

M Ebner, G Wang, W Li, M Aertsen, PA Patel… - NeuroImage, 2020 - Elsevier
High-resolution volume reconstruction from multiple motion-corrupted stacks of 2D slices
plays an increasing role for fetal brain Magnetic Resonance Imaging (MRI) studies …

[HTML][HTML] Animal models of fetal growth restriction: Considerations for translational medicine

AM Swanson, AL David - Placenta, 2015 - Elsevier
Fetal growth restriction (FGR) is the failure of a fetus to reach its full genetic growth potential.
It occurs in up to 8% of pregnancies, and after premature birth is the second leading cause …

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans

SD Castillo, E Tzouanacou, M Zaw-Thin… - Science translational …, 2016 - science.org
Venous malformations (VMs) are painful and deforming vascular lesions composed of
dilated vascular channels, which are present from birth. Mutations in the TEK gene …

Management and outcomes of extreme preterm birth

AS Morgan, M Mendonça, N Thiele, AL David - bmj, 2022 - bmj.com
Extreme preterm birth, defined as birth before 28 weeks' gestational age (box 1), 1 affects
about two to five in every 1000 pregnancies, and varies slightly by country and by definitions …

[HTML][HTML] Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response

D Chan, PR Bennett, YS Lee, S Kundu, TG Teoh… - Nature …, 2022 - nature.com
There has been a surge in studies implicating a role of vaginal microbiota in spontaneous
preterm birth (sPTB), but most are associative without mechanistic insight. Here we show a …