Intratracheal administration of clinical-grade mesenchymal stem cell-derived extracellular vesicles reduces lung injury in a rat model of bronchopulmonary dysplasia

A Porzionato, P Zaramella, A Dedja… - … of Physiology-Lung …, 2019 - journals.physiology.org
Mesenchymal stem cells (MSCs) prevent the onset of bronchopulmonary dysplasia (BPD) in
animal models, an effect that seems to be mediated by their secreted extracellular vesicles …

[HTML][HTML] Improvement of diaphragmatic performance through orthotopic application of decellularized extracellular matrix patch

…, L Urbani, ME Alvarez-Fallas, C Franzin, A Dedja… - Biomaterials, 2016 - Elsevier
Muscle tissue engineering can provide support to large congenital skeletal muscle defects
using scaffolds able to allow cell migration, proliferation and differentiation. Acellular …

Intratracheal administration of mesenchymal stem cell-derived extracellular vesicles reduces lung injuries in a chronic rat model of bronchopulmonary dysplasia

A Porzionato, P Zaramella, A Dedja… - … of Physiology-Lung …, 2021 - journals.physiology.org
Early therapeutic effect of intratracheally (IT)-administered extracellular vesicles secreted by
mesenchymal stem cells (MSC-EVs) has been demonstrated in a rat model of …

Human amniotic fluid stem cells protect rat lungs exposed to moderate hyperoxia

D Grisafi, M Pozzobon, A Dedja, V Vanzo… - Pediatric …, 2013 - Wiley Online Library
Background Treatment of bronchopulmonary dysplasia (BPD) remains as yet an unmet
clinical need and recently stem cells have been proposed as a therapeutic tool in animal …

[HTML][HTML] Porcine decellularized diaphragm hydrogel: a new option for skeletal muscle malformations

D Boso, E Carraro, E Maghin, S Todros, A Dedja… - Biomedicines, 2021 - mdpi.com
Hydrogels are biomaterials that, thanks to their unique hydrophilic and biomimetic
characteristics, are used to support cell growth and attachment and promote tissue …

Ureteral stenosis in HDAF pig‐to‐primate renal xenotransplantation: a phenomenon related to immunological events?

…, F Calabrese, R Cadrobbi, A Dedja… - American Journal of …, 2004 - Wiley Online Library
The aim of this study was to analyze the incidence of ureteral stenosis in a life‐supporting
human decay‐accelerating factor (hDAF) transgenic pig‐to‐cynomolgus monkey kidney …

[HTML][HTML] Decellularized diaphragmatic muscle drives a constructive angiogenic response in vivo

…, M Piccoli, C Franzin, A Sgrò, A Dedja… - International journal of …, 2018 - mdpi.com
Skeletal muscle tissue engineering (TE) aims to efficiently repair large congenital and
acquired defects. Biological acellular scaffolds are considered a good tool for TE, as …

[HTML][HTML] Allogenic tissue-specific decellularized scaffolds promote long-term muscle innervation and functional recovery in a surgical diaphragmatic hernia model

C Trevisan, E Maghin, A Dedja, P Caccin, N de Cesare… - Acta Biomaterialia, 2019 - Elsevier
Congenital diaphragmatic hernia (CDH) is a neonatal defect in which the diaphragm muscle
does not develop properly, thereby raising abdominal organs into the thoracic cavity and …

[HTML][HTML] Customized bioreactor enables the production of 3D diaphragmatic constructs influencing matrix remodeling and fibroblast overgrowth

E Maghin, E Carraro, D Boso, A Dedja… - NPJ Regenerative …, 2022 - nature.com
The production of skeletal muscle constructs useful for replacing large defects in vivo, such
as in congenital diaphragmatic hernia (CDH), is still considered a challenge. The standard …

Cardiac interstitial cells express GATA4 and control dedifferentiation and cell cycle re-entry of adult cardiomyocytes

T Zaglia, A Dedja, C Candiotto, E Cozzi… - Journal of molecular and …, 2009 - Elsevier
Interstitial cells of the adult rat heart were characterized with respect to i) expression of
cardiac markers of commitment and differentiation, ii) myogenic potential in vitro and iii) …