Hypoxic-ischaemic injury to the brain is an important cause of perinatal death and seems to
be the commonest cause of permanent neurodevelopmental disability in newborn infants …

To achieve diagnostic images during MRI examinations, small children need to lie still to
avoid movement artefact. To reduce patient motion, obviate the need for voluntary …

Magnetic resonance imaging (MRI) has proved to be a valuable tool for monitoring
development and pathology in the preterm brain. This imaging modality is useful for …

Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …

Background Cerebral hypothermia can improve outcome of experimental perinatal hypoxia-
ischaemia. We did a multicentre randomised controlled trial to find out if delayed head …

Background Whether hypothermic therapy improves neurodevelopmental outcomes in
newborn infants with asphyxial encephalopathy is uncertain. Methods We performed a …

Pattern-recognition receptors (PRRs) detect molecular signatures of microbes and initiate
immune responses to infection. Prototypical PRRs such as Toll-like receptors (TLRs) signal …

Objective To determine whether moderate hypothermia after hypoxic-ischaemic
encephalopathy in neonates improves survival and neurological outcome at 18 months of …

Phosphorus (31 P) spectra from the brains of severely birth-asphyxiated human infants are
commonly normal on the first day of life. Later, cerebral energy failure develops, which …

Background In the Total Body Hypothermia for Neonatal Encephalopathy Trial (TOBY),
newborns with asphyxial encephalopathy who received hypothermic therapy had improved …