Recombinant tissue-type plasminogen activator therapy of thrombosis in 16 neonates

J Pediatr. 1998 Jul;133(1):137-40. doi: 10.1016/s0022-3476(98)70193-3.

Abstract

We report 16 cases of neonatal vascular thrombosis treated with the same protocol for recombinant tissue-type plasminogen activator infusion. Flow restoration was complete in seven patients, partial in seven, and absent in two. Safety was satisfactory provided contraindications were respected.

MeSH terms

  • Fibrinolytic Agents / therapeutic use
  • Heparin / therapeutic use
  • Humans
  • Infant
  • Infant, Newborn
  • Plasminogen Activators / adverse effects
  • Plasminogen Activators / therapeutic use*
  • Recombinant Proteins
  • Retrospective Studies
  • Risk Factors
  • Thrombosis / drug therapy*
  • Thrombosis / mortality
  • Tissue Plasminogen Activator / adverse effects
  • Tissue Plasminogen Activator / therapeutic use*
  • Treatment Outcome

Substances

  • Fibrinolytic Agents
  • Recombinant Proteins
  • Heparin
  • Plasminogen Activators
  • Tissue Plasminogen Activator