Abstract
We prospectively analyzed airway specimens from 24 newborn infants. Inhaled nitric oxide (< or = 20 ppm for 1 to 4 days to 12 infants) did not affect the concentrations of the lipid peroxidation product, the surface activity, or the cytokines (interleukin-1, granulocyte-macrophage colony-stimulating factor, interleukin-1 receptor antagonist). Nitrotyrosine was detected after 10 days of life in the two infants requiring prolonged ventilation, suggesting toxicity of endogenous nitric oxide.
Publication types
-
Clinical Trial
-
Comparative Study
-
Controlled Clinical Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cytokines / metabolism
-
Female
-
Humans
-
Infant, Newborn
-
Lipid Peroxidation / drug effects
-
Male
-
Nitric Oxide / administration & dosage
-
Nitric Oxide / adverse effects*
-
Nitric Oxide / metabolism
-
Persistent Fetal Circulation Syndrome / complications
-
Persistent Fetal Circulation Syndrome / drug therapy*
-
Persistent Fetal Circulation Syndrome / metabolism
-
Prospective Studies
-
Respiration, Artificial
-
Respiratory Distress Syndrome, Newborn / etiology*
-
Respiratory Distress Syndrome, Newborn / metabolism
-
Tyrosine / analogs & derivatives*
-
Tyrosine / analysis
Substances
-
Cytokines
-
Nitric Oxide
-
3-nitrotyrosine
-
Tyrosine