Abstract
The physiological role of K+ channel opening by endogenous substances (e.g., neurotransmitters and hormones) is a recognised inhibitory mechanism. Thus, the identification of novel synthetic molecules that 'directly' open K+ channels has led to a new direction in the pharmacology of ion channels. The existence of many different subtypes of K+ channels has been an impetus in the search for new molecules demonstrating channel and, thus, tissue selectivity. This review focuses on the different classes of openers of K+ channels, the intracellular mechanisms involved in the execution of their effects, and potential therapeutic targets.
MeSH terms
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Anti-Arrhythmia Agents / pharmacology
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Anti-Arrhythmia Agents / therapeutic use*
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Antihypertensive Agents / pharmacology
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Antihypertensive Agents / therapeutic use*
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Benzopyrans / pharmacology
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Benzopyrans / therapeutic use
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Bronchodilator Agents / pharmacology
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Bronchodilator Agents / therapeutic use*
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Calcium / metabolism
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Cardiovascular Diseases / drug therapy
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Cromakalim
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Hair / drug effects
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Hair / growth & development
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Humans
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Intraocular Pressure / drug effects
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Muscle, Skeletal / drug effects
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Nervous System Diseases / drug therapy
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Parasympatholytics / pharmacology
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Parasympatholytics / therapeutic use*
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Patch-Clamp Techniques
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Potassium Channels / drug effects*
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Potassium Channels / physiology
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Pyrroles / pharmacology
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Pyrroles / therapeutic use
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Reproduction / drug effects
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Respiratory Tract Diseases / drug therapy
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Synaptic Transmission / drug effects*
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Urologic Diseases / drug therapy
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Vasodilator Agents / pharmacology
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Vasodilator Agents / therapeutic use*
Substances
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Anti-Arrhythmia Agents
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Antihypertensive Agents
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Benzopyrans
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Bronchodilator Agents
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Parasympatholytics
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Potassium Channels
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Pyrroles
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Vasodilator Agents
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Cromakalim
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Calcium