Quality of life (QoL) was assessed in 85 young adults, born in 1971-1974 with birthweights < 1500 g (VLBW) and admitted to the neonatal intensive care unit of the State University Hospital in Copenhagen, Denmark. Their QoL was compared to that of 85 subjects with birthweights > 2500 g (NBW) born in the same period at the State University Hospital. The subjects were interviewed by telephone on the basis of the well-defined theories on QoL by Anton Aggernaes. Quality of life was assessed both in objective terms and as judged by the interviewed person. Subjects born with VLBWs and free of handicaps had QoL scores (both objective and subjective) fully comparable with the NBW group. VLBW subjects reporting various physical and mental handicaps had objective as well as subjective QoL scores significantly lower than the NBW group.