The treatment of neonatal meningitis due to gram-negative bacilli with ciprofloxacin: evidence of satisfactory penetration into the cerebrospinal fluid

S D Green; F Ilunga; J S Cheesbrough; G S Tillotson; M Hichens; D Felmingham

doi:10.1016/0163-4453(93)95291-p

The treatment of neonatal meningitis due to gram-negative bacilli with ciprofloxacin: evidence of satisfactory penetration into the cerebrospinal fluid

J Infect. 1993 May;26(3):253-6. doi: 10.1016/0163-4453(93)95291-p.

Authors

S D Green¹, F Ilunga, J S Cheesbrough, G S Tillotson, M Hichens, D Felmingham

Affiliation

¹ Department of Paediatrics, Institut Médical Evangélique, Kimpese, Zaïre.

PMID: 8505559
DOI: 10.1016/0163-4453(93)95291-p

Abstract

We describe two cases of neonatal meningitis due to Gram-negative bacilli treated successfully with ciprofloxacin. Examination of serial samples of cerebrospinal fluid indicated the effect of meningeal inflammation on penetration of this drug into the CSF.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Ciprofloxacin / cerebrospinal fluid*
Ciprofloxacin / therapeutic use*
Escherichia coli Infections / cerebrospinal fluid
Escherichia coli Infections / drug therapy*
Flavobacterium / isolation & purification
Gram-Negative Bacterial Infections / cerebrospinal fluid
Gram-Negative Bacterial Infections / drug therapy*
Humans
Infant, Newborn
Male
Meningitis, Bacterial / cerebrospinal fluid
Meningitis, Bacterial / drug therapy*

Substances

Ciprofloxacin