Abstract
Raised concentrations of soluble intracellular adhesion molecule 1 (sICAM-1) in tracheal aspirates from premature infants may predict development of bronchopulmonary dysplasia (BPD). We measured sICAM-1 in tracheal aspirates and serum samples from 15 newborn babies (9 with BPD, 6 without BPD) at 2-4, 6-7, and 12-14 days of age. sICAM-1 concentrations in tracheal aspirates were significantly raised at 6-7 and 12-14 days of age in infants who later developed BPD compared with infants who did not develop BPD. Serum samples from the two groups did not differ significantly in sICAM-1. Raised sICAM-1 in tracheal aspirate was a good predictor of lung injury in infants who later developed BPD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, CD / analysis*
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Antigens, CD / chemistry
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Bacterial Infections / metabolism
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Bronchopulmonary Dysplasia / blood
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Bronchopulmonary Dysplasia / metabolism*
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Cell Adhesion Molecules / analysis*
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Cell Adhesion Molecules / chemistry
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Female
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Humans
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Infant, Newborn
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Infant, Premature
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Intercellular Adhesion Molecule-1
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Intubation, Intratracheal
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Male
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Pneumonia / blood
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Pneumonia / metabolism
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Respiration, Artificial
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Respiratory Distress Syndrome, Newborn / blood
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Respiratory Distress Syndrome, Newborn / metabolism
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Retrospective Studies
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Solubility
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Suction
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Trachea / chemistry*
Substances
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Antigens, CD
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Cell Adhesion Molecules
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Intercellular Adhesion Molecule-1