Cranial computed tomography (CT) scans of 10 cases of perinatal hypoxia and 9 cases of perinatal hypoglycemia were reviewed. Emphasis was placed on follow-up studies. Periventricular hypodensity and intracranial (subarachnoidal and/or intraventricular) hemorrhage were the most frequent findings in the early CT scans of perinatal hypoxia. In the follow-up studies of the cases with periventricular hypodensity, return to normality was observed in most instances. In neonatal hypoglycemia, the findings were similar except for the rarity of intracranial bleeding.