Neonatal screening for congenital adrenal hyperplasia using 17-hydroxyprogesterone assay in filter paper blood spots

A Larsson; L Hagenfeldt; U von Döbeln; T Curstedt; J Gustafsson; E Svensson

doi:10.1159/000181069

Neonatal screening for congenital adrenal hyperplasia using 17-hydroxyprogesterone assay in filter paper blood spots

Horm Res. 1988;30(6):235-40. doi: 10.1159/000181069.

Authors

A Larsson¹, L Hagenfeldt, U von Döbeln, T Curstedt, J Gustafsson, E Svensson

Affiliation

¹ Department of Bacteriology, National Bacteriological Laboratory, Stockholm, Sweden.

PMID: 3250925
DOI: 10.1159/000181069

Abstract

Screening of infants for congenital adrenal hyperplasia (CAH) using filter paper blood samples collected on the 5th day of life was performed with a radioimmunoassay for 17-hydroxyprogesterone without extraction with organic solvents. A total of 153,000 newborns were screened and 12 cases of CAH were detected (1:12,800). With recall levels related to gestational age, the recall rate could be lowered to 0.05%.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

17-alpha-Hydroxyprogesterone
Adrenal Hyperplasia, Congenital / blood
Adrenal Hyperplasia, Congenital / diagnosis*
Biomarkers / blood*
Female
Gestational Age
Humans
Hydroxyprogesterones / blood*
Infant, Newborn
Infant, Premature
Male
Mass Screening
Paper
Radioimmunoassay
Reference Values

Substances

Biomarkers
Hydroxyprogesterones
17-alpha-Hydroxyprogesterone