Reference Intervals in Neonatal Hematology

Erick Henry; Robert D Christensen

doi:10.1016/j.clp.2015.04.005

Reference Intervals in Neonatal Hematology

Clin Perinatol. 2015 Sep;42(3):483-97. doi: 10.1016/j.clp.2015.04.005. Epub 2015 May 13.

Authors

Erick Henry¹, Robert D Christensen²

Affiliations

¹ Women and Newborn's Program, Intermountain Healthcare, 36 S. State Street, Salt Lake City, UT 84111, USA; The Institute for Healthcare Delivery Research, 36 S. State Street Salt Lake City, UT 84111, USA. Electronic address: Erick.henry@imail.org.
² Women and Newborn's Program, Intermountain Healthcare, 36 S. State Street, Salt Lake City, UT 84111, USA; Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, 295 Chipeta Way, Salt Lake City, UT, 84108 USA; Division of Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, 295 Chipeta Way, Salt Lake City, UT, 84108 USA.

PMID: 26250912
DOI: 10.1016/j.clp.2015.04.005

Abstract

The various blood cell counts of neonates must be interpreted in accordance with high-quality reference intervals based on gestational and postnatal age. Using very large sample sizes, we generated neonatal reference intervals for each element of the complete blood count (CBC). Knowledge of whether a patient has CBC values that are too high (above the upper reference interval) or too low (below the lower reference interval) provides important insights into the specific disorder involved and in many instances suggests a treatment plan.

Keywords: Anemia; CBC; Complete blood count; Erythrocyte indices; Hemoglobin; Leukocytes; Platelets.

Publication types

Review

MeSH terms

Blood Cell Count / standards*
Hematology / standards*
Humans
Infant, Newborn
Reference Values