School-age outcomes following a randomized controlled trial of magnesium sulfate for neuroprotection of preterm infants

Clément Chollat; Maya Enser; Estelle Houivet; Delphine Provost; Jacques Bénichou; Loïc Marpeau; Stéphane Marret

doi:10.1016/j.jpeds.2014.04.007

School-age outcomes following a randomized controlled trial of magnesium sulfate for neuroprotection of preterm infants

J Pediatr. 2014 Aug;165(2):398-400.e3. doi: 10.1016/j.jpeds.2014.04.007. Epub 2014 May 14.

Authors

Clément Chollat¹, Maya Enser², Estelle Houivet³, Delphine Provost², Jacques Bénichou³, Loïc Marpeau⁴, Stéphane Marret⁵

Affiliations

¹ Department of Neonatal Pediatrics and Intensive Care, Rouen University Hospital, Rouen, France; Region INSERM Team 28 "NeoVasc", Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Institute for Biomedical Research, Rouen University, Rouen, France. Electronic address: clement.chollat@chu-rouen.fr.
² Department of Anesthetics and Intensive Care, Rouen University Hospital, Rouen, France.
³ Department of Biostatistics, Rouen University Hospital, Rouen, France.
⁴ Region INSERM Team 28 "NeoVasc", Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Institute for Biomedical Research, Rouen University, Rouen, France; Department of Obstetrics and Gynecology, Rouen University Hospital, Rouen, France.
⁵ Department of Neonatal Pediatrics and Intensive Care, Rouen University Hospital, Rouen, France; Region INSERM Team 28 "NeoVasc", Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Institute for Biomedical Research, Rouen University, Rouen, France.

PMID: 24837863
DOI: 10.1016/j.jpeds.2014.04.007

Abstract

In a French randomized trial, children at school-age demonstrated no evidence of harm from fetal exposure to MgSO4 before very preterm birth. Motor dysfunction/death, qualitative behavioral disorders, cognitive difficulties, school grade repetition, and education services were decreased in the children exposed to MgSO4, although the differences were not significant.

Trial registration: ClinicalTrials.gov NCT00120588.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Cerebral Palsy / prevention & control*
Child
Female
Follow-Up Studies
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / prevention & control*
Magnesium Sulfate / adverse effects
Magnesium Sulfate / therapeutic use*
Male
Neuroprotective Agents / adverse effects
Neuroprotective Agents / therapeutic use*
Pregnancy
Prenatal Exposure Delayed Effects*
Psychomotor Performance / drug effects
Psychomotor Performance / physiology
Surveys and Questionnaires
Treatment Outcome

Substances

Neuroprotective Agents
Magnesium Sulfate

Associated data

ClinicalTrials.gov/NCT00120588