A randomized controlled trial of 1% aqueous chlorhexidine gluconate compared with 10% povidone-iodine for topical antiseptic in neonates: effects on blood culture contamination rates

Pracha Nuntnarumit; Nartsiri Sangsuksawang

doi:10.1086/669863

A randomized controlled trial of 1% aqueous chlorhexidine gluconate compared with 10% povidone-iodine for topical antiseptic in neonates: effects on blood culture contamination rates

Infect Control Hosp Epidemiol. 2013 Apr;34(4):430-2. doi: 10.1086/669863. Epub 2013 Feb 14.

Authors

Pracha Nuntnarumit¹, Nartsiri Sangsuksawang

Affiliation

¹ Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. pracha.nun@mahidol.ac.th

PMID: 23466918
DOI: 10.1086/669863

Abstract

We conducted a randomized controlled trial in neonates with birth weight greater than or equal to 1,500 g that compared 1% aqueous chlorhexidine gluconate (CHG) with 10% povidone-iodine (PI) as a topical antiseptic. We found 1% CHG to be more effective than 1% PI in reducing blood culture contamination rates, and no contact dermatitis was observed.

Publication types

Comparative Study
Randomized Controlled Trial

MeSH terms

Administration, Cutaneous
Anti-Infective Agents, Local* / administration & dosage
Anti-Infective Agents, Local* / adverse effects
Antisepsis / methods*
Blood / microbiology*
Blood Specimen Collection / methods*
Chlorhexidine / administration & dosage
Chlorhexidine / adverse effects
Chlorhexidine / analogs & derivatives*
Humans
Infant, Newborn
Outcome Assessment, Health Care
Povidone-Iodine* / administration & dosage
Povidone-Iodine* / adverse effects
Skin / drug effects
Skin / microbiology*
Staphylococcus epidermidis / isolation & purification

Substances

Anti-Infective Agents, Local
Povidone-Iodine
chlorhexidine gluconate
Chlorhexidine