Selective serotonin reuptake inhibitor (SSRI) use during pregnancy and effects on the fetus and newborn: a meta-analysis

J Perinatol. 2005 Sep;25(9):595-604. doi: 10.1038/sj.jp.7211352.

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are frequently used to treat depression during pregnancy and the postpartum period. These drugs are capable of crossing the placenta and being transferred to the newborn during lactation. This report reviews the available information regarding the effects of SSRIs on the fetus and newborn; including long-term neurodevelopmental outcomes.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child Development / drug effects
  • Female
  • Fetus / drug effects*
  • Humans
  • Infant, Newborn / physiology*
  • Maternal-Fetal Exchange
  • Pregnancy
  • Selective Serotonin Reuptake Inhibitors / adverse effects*

Substances

  • Serotonin Uptake Inhibitors