Abstract
Aim:
To evaluate the effect of a change in antibiotic protocol on pathogens that cause neonatal sepsis.
Methods:
Suspected sepsis was treated with amikacin together with ceftazidime in 1995-1998 and piperacillin/tazobactam in 1999-2002.
Results:
The annual rate for Klebsiella sepsis fell from 2.5 to 0.45 cases per 1000 admission days (p = 0.0001) between the two periods studied.
Conclusion:
The change from ceftazidime to piperacillin/tazobactam is associated with a decrease in the incidence of Klebsiella sepsis.
MeSH terms
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Anti-Bacterial Agents / therapeutic use*
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Ceftazidime / therapeutic use
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Cross Infection / epidemiology
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Cross Infection / prevention & control*
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Drug Resistance, Multiple, Bacterial / drug effects*
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Humans
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Infant, Newborn
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Infection Control
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Israel / epidemiology
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Klebsiella Infections / epidemiology
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Klebsiella Infections / prevention & control*
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Penicillanic Acid / analogs & derivatives
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Penicillanic Acid / therapeutic use*
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Piperacillin / therapeutic use*
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Piperacillin, Tazobactam Drug Combination
Substances
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Anti-Bacterial Agents
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Piperacillin, Tazobactam Drug Combination
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Penicillanic Acid
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Ceftazidime
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Piperacillin