Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn

Lancet. 1992 Oct 3;340(8823):819-20. doi: 10.1016/0140-6736(92)92687-b.

Abstract

We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of systemic blood pressure. In 6 infants treated with inhaled NO for 24 h, clinical improvement was sustained at 6 ppm.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Inhalation
  • Blood Pressure
  • Carbon Dioxide / blood
  • Extracorporeal Membrane Oxygenation
  • Humans
  • Infant, Newborn
  • Methemoglobin / analysis
  • Nitric Oxide / administration & dosage
  • Nitric Oxide / therapeutic use*
  • Oxygen / blood
  • Persistent Fetal Circulation Syndrome / blood
  • Persistent Fetal Circulation Syndrome / drug therapy*

Substances

  • Carbon Dioxide
  • Nitric Oxide
  • Methemoglobin
  • Oxygen