Abstract
Platelet production is primarily regulated by the thrombopoietic cytokine thrombopoietin (TPO). In most cases thrombopoietin serum levels are determined by the rate of c-mpl receptor-mediated degradation after TPO uptake into platelets and megakaryocytes. The contribution of increased TPO protein synthesis by a translational mechanism was recently appreciated as the cause for hereditary thrombocythemia and will have to be elucidated in other conditions of thrombocytosis in association with increased TPO levels.
MeSH terms
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Acquired Immunodeficiency Syndrome / blood
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Adult
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Animals
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Antineoplastic Agents / adverse effects
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Child, Preschool
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Cytokines / blood
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Cytokines / pharmacology
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HIV Infections / blood
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Hematologic Diseases / blood
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Hematologic Diseases / chemically induced
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Hematologic Diseases / genetics
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Humans
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Infant
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Infant, Newborn
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Neoplasm Proteins*
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Proto-Oncogene Proteins / metabolism
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Receptors, Cytokine / metabolism
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Receptors, Thrombopoietin
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Thrombocytopenia / blood
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Thrombocytosis / etiology
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Thrombocytosis / metabolism
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Thrombocytosis / virology
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Thrombopoietin / blood*
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Thrombopoietin / drug effects
Substances
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Antineoplastic Agents
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Cytokines
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Neoplasm Proteins
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Proto-Oncogene Proteins
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Receptors, Cytokine
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Receptors, Thrombopoietin
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MPL protein, human
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Thrombopoietin