Abstract
There is substantial clinical evidence that the incidence of depression and mortality after acute coronary events are strongly related. As mediators of coronary thrombosis, platelets may represent a link between these events, and could be possibly targeted by therapy with serotonin reuptake inhibitors.
MeSH terms
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Animals
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Antidepressive Agents / pharmacology
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Antidepressive Agents / therapeutic use*
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Blood Platelets / drug effects
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Blood Platelets / metabolism*
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Clinical Trials as Topic
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Depression / complications*
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Depression / drug therapy*
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Humans
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Myocardial Infarction / blood
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Myocardial Infarction / mortality
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Myocardial Infarction / psychology*
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Risk Factors
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Selective Serotonin Reuptake Inhibitors / pharmacology
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Selective Serotonin Reuptake Inhibitors / therapeutic use*
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Sertraline / pharmacology
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Sertraline / therapeutic use*
Substances
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Antidepressive Agents
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Serotonin Uptake Inhibitors
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Sertraline