Chest
Original ResearchPediatricsEncouraging Pulmonary Outcome for Surviving, Neurologically Intact, Extremely Premature Infants in the Postsurfactant Era
Section snippets
Subjects
Children born between 1997 and 2001 at a gestational age of ≤ 28 weeks at Schneider Children's Medical Center of Israel (SCMCI) and surviving to mid-childhood were divided into two groups: (1) those with BPD and (2) those without BPD (non-BPD). Although the definition of BPD can be argued, we used the National Institutes of Health consensus definition and severity grading (lung disease requiring oxygen supplementation at 28 days, severity graded by oxygen requirement at a corrected gestational
Results
The attrition of the index study group is described in Figure 1. Of note, of the 87 infants who died before discharge, 70 had severe respiratory disease that often was related to extreme prematurity and contributed at least in part to their deaths. Twenty-eight of 54 survivors of BPD fulfilling inclusion criteria (including all seven with moderate BPD) and 25 of 106 survivors without BPD were recruited, and 23 healthy children comprised the control group. The 53 recruited subjects were of
Discussion
In extremely premature infants, immature lungs are still among the limiting factors for survival and a major cause of neonatal morbidity. This study explores respiratory outcome at mid-childhood in the postsurfactant era, comparing 28 BPD survivors born at a mean gestational age of 26 weeks to 25 non-BPD survivors and 23 term healthy control children.
In this SCMCI cohort, only 192 of 279 infants survived to discharge, and many died of respiratory complications, including severe BPD, as found by
Acknowledgments
Author contributions: Dr Blau had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Dr Kaplan: contributed to the study conception and design, patient recruitment, performance of lung function tests, analysis and interpretation of data, and writing of the manuscript.
Dr Bar-Yishay: contributed to the performance of lung function tests, analysis and interpretation of data, and revision of the manuscript.
Dr
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2024, British Journal of AnaesthesiaExercise capacity in children with bronchopulmonary dysplasia at school age
2020, Respiratory MedicineCitation Excerpt :This corresponds to the likewise reduced workload of the BPD group compared to the age-matched control group. As in some prior investigations, this parameter remains significantly different between the groups even after adjusting for body weight [8,27]. Given that the exercise status is largely similar, the differences in respiratory complaints and workload may be the result of the pulmonary obstruction and increased work of breathing, resulting in compensatory mechanisms, such as lowering minute ventilation at exercise [20].
Lung imaging in bronchopulmonary dysplasia: a systematic review
2020, Respiratory MedicineCitation Excerpt :Children with BPD are more often hospitalized for respiratory problems within the first two years of life [12,13]. Preschoolers, school-aged children, and young adults with BPD are at increased risk of asthma [14–18]. Numerous studies have shown an impaired lung function with obstruction throughout childhood into early adulthood [12,14,15,19–26].
Aerobic Capacity of Preterm Children with Very Low Birth Weight at School Age and its Associated Factors
2020, Archivos de BronconeumologiaCitation Excerpt :As previously demonstrated, PuO2 is dependent on the VO2 peak, as girls had lesser PuO2, may be associated with the lower VO2 peak presented.26,27 Ventilatory reserve expressed as TV/IC peak ratio is expected to be associated with some independent variables because of the presence of BPD or prematurity itself, as previously reported in the literature.2,4,8 This association was expected because preterm infants may present pulmonary hyperinflation, which would reduce the tidal volume and inspiratory capacity to exercise.
Investigation and management of the long-term ventilated premature infant
2018, Early Human DevelopmentCitation Excerpt :These criteria are now widely used by healthcare professionals for the diagnosis of BPD. However, it should be noted that although the NICHD definition more accurately predicts pulmonary outcomes, including the need for medications and likelihood of rehospitalisation, at 18–22 months CGA than its predecessors [4], it does not correlate with results of pulmonary function testing at 8–10 years of age [5,6]. BPD is the most common chronic lung disease of infancy, with up to 10,000 new cases seen in the USA each year.
Funding/Support: This study was supported by a grant from the Israel Association for Clinical Pediatrics.
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