Elsevier

Seminars in Neonatology

Volume 5, Issue 1, February 2000, Pages 3-16
Seminars in Neonatology

Regular Article
Mechanisms of perinatal brain injury

https://doi.org/10.1053/siny.1999.0112Get rights and content

Abstract

This article is focused on the mechanisms underlying primarily ischaemic/reperfusion brain injury in both the term and premature infant. Although the mechanisms involved include similar initiating events, principally ischaemia–reperfusion, and similar final common pathways to cell death, particularly free radical-mediated events, there are certain unique maturational factors influencing the type and pattern of cellular injury. We will therefore initially describe the physiological and cellular/molecular mechanisms of brain injury in the term infant, followed by the mechanisms in the premature infant.

References (130)

  • JJ Volpe

    Brain injury in the premature infant. Neuropathology, clinical aspects, pathogenesis, and prevention

    Clin Perinatol

    (1997)
  • S Takashima et al.

    Pathogenesis of periventricular white matter hemorrhages in preterm infants

    Brain Dev

    (1986)
  • LR Ment

    Risk factors for early intraventricular hemorrhage in low birth weight infants

    J Pediatr

    (1992)
  • LS de Vries et al.

    The spectrum of leukomalacia using cranial ultrasound

    Behav Brain Res

    (1992)
  • K Iida et al.

    Immunohistochemical study of myelination and oligodendrocyte in infants with periventricular leukomalacia

    Pediatr Neurol

    (1995)
  • N Paneth

    White matter necrosis in very low birth weight infants: neuropathologic and ultrasonographic findings in infants surviving six days or longer

    J Pediatr

    (1990)
  • S Takashima et al.

    Periventricular leukomalacia, glial development and myelination

    Early Hum Dev

    (1995)
  • BH Yoon

    Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia

    Am J Obstet Gynecol

    (1996)
  • BH Yoon

    High expression of tumor necrosis factor-alpha and interleukin-6 in periventricular leukomalacia

    Am J Obstet Gynecol

    (1997)
  • K Iida

    Neuropathologic study of newborns with prenatal-onset leukomalacia

    Pediatr Neurol

    (1993)
  • S Takashima

    Relationship between periventricular hemorrhage, leukomalacia and brainstem lesions in prematurely born infants

    Brain Dev

    (1989)
  • G Greisen et al.

    Low CBF, discontinuous EEG activity, and periventricular brain injury in ill, preterm neonates

    Brain Dev

    (1989)
  • O Pryds

    Heterogeneity of cerebral vasoreactivity in preterm infants supported by mechanical ventilation

    J Pediatr

    (1989)
  • O Pryds et al.

    Preservation of single-flash visual evoked potentials at very low cerebral oxygen delivery in preterm infants

    Pediatr Neurol

    (1990)
  • AW Brown et al.

    The earliest alterations in the rat neurons and astrocytes after anoxia-ischemia

    Acta Neuropathol

    (1973)
  • SU Kim

    Brain hypoxia studied in mouse central nervous system cultures. 1. Sequential cellular changes

    Lab Invest

    (1975)
  • JC Larroche

    Developmental Pathology of the Neonate

    (1977)
  • JJ Volpe

    Neurology of the Newborn

    (1995)
  • CE Williams

    Outcome after ischemia in the developing sheep brain: an electroencephalographic and histological study

    Ann Neurol

    (1992)
  • EC Mallard

    Frequent episodes of brief ischemia sensitize the fetal sheep brain to neuronal loss and induce striatal injury

    Pediatr Res

    (1993)
  • R Busto

    The importance of brain temperature in cerebral ischemic injury

    Stroke

    (1989)
  • H Minamisawa et al.

    The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia

    Ann Neurol

    (1990)
  • ES Sirimanne

    The effect of prolonged modification of cerebral temperature on outcome after hypoxic-ischemic brain injury in the infant rat

    Pediatr Res

    (1996)
  • PD Gluckman et al.

    When and why do brain cells die?

    Dev Med Child Neurol

    (1992)
  • A Lorek

    Delayed (“secondary”) cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy

    Pediatr Res

    (1994)
  • J Penrice

    Proton magnetic resonance spectroscopy of the brain in normal preterm and term infants, and early changes after perinatal hypoxia-ischemia

    Pediatr Res

    (1996)
  • S Orrenius

    Calcium ions and oxidative cell injury

    Ann Neurol

    (1992)
  • S Marret

    Effect of ibotenate on brain development: an excitotoxic mouse model of microgyria and posthypoxic-like lesions

    J Neuropathol Exp Neurol

    (1995)
  • AJ Gunn

    Flunarizine, a calcium channel antagonist, is partially prophylactically neuroprotective in hypoxic-ischemic encephalopathy in the fetal sheep

    Pediatr Res

    (1994)
  • JM Goplerud et al.

    Brain cell membrane dysfunction following acute asphyxia in newborn piglets

    Biol Neonate

    (1992)
  • CE Williams et al.

    Time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep

    Stroke

    (1991)
  • WK Tan

    Suppression of postischemic epileptiform activity with MK-801 improves neural outcome in fetal sheep

    Ann Neurol

    (1992)
  • WK Tan

    Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep

    Pediatr Res

    (1996)
  • KA Marks

    Delayed vasodilation and altered oxygenation after cerebral ischemia in fetal sheep

    Pediatr Res

    (1996)
  • KA Marks

    Nitric oxide synthase inhibition attenuates delayed vasodilation and increases injury after cerebral ischemia in fetal sheep

    Pediatr Res

    (1996)
  • EC Mallard

    Neuronal damage in the developing brain following intrauterine asphyxia

    Reprod Fertil Dev

    (1995)
  • AJ Gunn

    Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs

    J Clin Invest

    (1997)
  • SC Roth

    Relation of deranged neonatal cerebral oxidative metabolism with neurodevelopmental outcome and head circumference at 4 years

    Dev Med Child Neurol

    (1997)
  • M Hack et al.

    Outcomes of extremely low birth weight infants

    Pediatrics

    (1996)
  • JD Horbar

    Vermont-Oxford Network 1997 Database Summary

    (1997)
  • Cited by (0)

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    Correspondence to: Joseph J. Volpe, Neurologist-in-Chief, Neurology Department, Fegan 1103, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, U S A. Tel: 617–355–6386; Fax: 617–730–0416; Email:[email protected]

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