Elsevier

Genetics in Medicine

Volume 14, Issue 11, November 2012, Pages 905-913
Genetics in Medicine

Original Research Article
Women’s and health professionals’ preferences for prenatal tests for Down syndrome: a discrete choice experiment to contrast noninvasive prenatal diagnosis with current invasive tests

https://doi.org/10.1038/gim.2012.68Get rights and content
Under an Elsevier user license
open archive

Abstract

Purpose

To compare the preferences of women and health professionals for key attributes of noninvasive prenatal diagnosis for Down syndrome relative to current invasive tests.

Methods

A questionnaire incorporating a discrete choice experiment was used to obtain participants’ stated preference for diagnostic tests that varied according to four attributes: accuracy, time of test, risk of miscarriage, and provision of information about Down syndrome only or Down syndrome and other conditions. Women and health professionals were recruited from five maternity services in England and a patient support group.

Results

Questionnaires from 335 women and 181 health professionals were analyzed. Safe tests, conducted early in pregnancy, with high accuracy and information about Down syndrome and other conditions were preferred. The key attribute affecting women’s preferences for testing was no risk of miscarriage, whereas for health professionals it was accuracy.

Conclusions

Policies for implementing noninvasive prenatal diagnosis must consider the differences between women’s and health professionals’ preferences to ensure the needs of all stakeholders are met. Women’s strong preference for tests with no risk of miscarriage demonstrates that consideration for safety of the fetus is paramount in decision making. Effective pretest counseling is therefore essential to ensure women understand the possible implications of results.

Genet Med 2012:14(11):905–913

Keywords

discrete choice experiment
Down syndrome
non-invasive prenatal diagnosis

Cited by (0)