Congenital malformations associated with assisted reproductive technology: A California statewide analysis☆,☆☆
Section snippets
Data source
This retrospective cohort study was performed after obtaining IRB approvals from the University of California, Los Angeles and the California Office of Statewide Health Planning and Development (OSHPD). Data were obtained from the California Patient Discharge Linked Birth Cohort Database [11]. OSHPD collects annual data of all infants and mothers discharged from non-federal hospitals licensed in California. A discharge abstract is reported for each inpatient hospitalization and includes:
Results
Overall, a total of 1,749 infants born after FRS and 4,795 infants born after ART were identified and matched to 17,476 and 46,025 naturally conceived controls respectively (Table 1). Maternal age, race, parity and plurality did not significantly differ between infants born after FRS and matched controls. Infants born after ART had slightly older mothers and were more likely to be a multiple when compared to matched controls.
Infants born after FRS were slightly younger, more likely to be
Discussion
The pediatric surgeon and other pediatric healthcare providers are often consulted when a congenital malformation is diagnosed prenatally and/or postnatally. Understanding the components of the mother’s prenatal history, including use of fertility assistive services, is important in order to properly counsel parents regarding their child's prospective risk profile, factors complicating the delivery, and anticipated needs for specialized neonatal medical and surgical care. This study focuses on
Acknowledgments
The authors would like to sincerely thank Kara Calkins, M.D. from the UCLA Division of Neonatology for her insight and recommendations for the manuscript preparation.
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Cited by (28)
Assisted reproductive technologies and the risk of congenital urogenital tract malformations: A systematic review and meta-analysis
2021, Journal of Pediatric UrologyCitation Excerpt :All analyses were performed with STATA/SE 15.0 software (StataCorp, College Station, TX, USA). We screened a total of 33 papers that met the criteria, namely, 1 case–control study [18] (matched for maternal age and birth condition), 29 retrospective cohort studies [9–11,14,19–43], and 3 prospective cohort studies [44–46]. A total of 1316 cases of ART offspring with urogenital tract malformations and 24,516 cases of naturally conceived offspring with urogenital tract malformations were noted.
Vascular Health of Children Conceived via In Vitro Fertilization
2019, Journal of PediatricsFertility Treatment Is Associated with Stay in the Neonatal Intensive Care Unit and Respiratory Support in Late Preterm Infants
2017, Journal of PediatricsCitation Excerpt :It remains to be determined whether it is the fertility treatment and/or the underlying infertility that contributes to adverse outcomes. Although some studies have concluded that pregnancies conceived with fertility treatment are comparable with spontaneous conceptions in terms of cytogenetic abnormalities,23,24 other studies have identified an increased risk of birth defects25-27 associated with fertility treatment. The developmental origin of health and disease hypothesis suggests that specific windows of sensitivity during fetal development allow environmental exposures to reprogram the genome and predispose to disease later in life.28
Congenital heart disease in twins: The contribution of type of conception and chorionicity
2016, International Journal of CardiologyCitation Excerpt :A limited number of studies have specifically addressed the association of ART and CHD, with conflicting results [31–35]. Recent reports suggest that the increased incidence of cardiac malformations in these pregnancies is mainly explained by the contribution of multiple gestations and that singletons conceived with IVF may not be at increased risk for birth defects [28,34,36,37]. Nevertheless, the overall risk of CHD in infants conceived by ART seems to be slightly higher than that of the general population [37].
Birth defects and assisted reproductive technologies
2014, Seminars in Fetal and Neonatal MedicineCitation Excerpt :Especially egregious is, as noted, assuming that results derived from methods used long ago are still generalizable to the contemporary patient, a concern raised earlier. The most contemporary study involves 2006–2007 cycles, well behind currently used techniques like vitrification [15]. The long interval between pregnancies analyzed and publication data makes generalizability to women undergoing ART in 2014 arguable.
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Funding/Support: Dr. Kelley-Quon is supported by the Robert Wood Johnson Foundation. Dr. Stephen Shew is supported in part by NIH grant HD052885.
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Role of the Sponsor: The Robert Wood Johnson Foundation had no role in the preparation, review, or approval of the manuscript.